Mr Alexander Underwood – Characterising broad neutralising antibody responses in natural HCV infection: implications & challenges for vaccine design

Event type: 
Event date: 
Tuesday, 11 June 2019 - 1:00pm to 2:00pm

Berg Family Foundation Seminar Room, Level 6, Wallace Wurth Building, Kensington Campus

Contact for inquiries: 
Rata Joseph, +61 (2) 9385 0900 or
Booking deadline: 

Kirby Institute Seminar Series presents

Mr Alexander Underwood

Mr Alexander Underwood

PhD Student, Viral Immunology Systems Program, Kirby Institute

Alexander Underwood is a PhD candidate in the Viral Immunology Systems Program, Kirby Institute, with his thesis focusing on understanding the role of broadly neutralising antibodies in HCV infection. During this seminar, he will present the body of work that has been completed during his candidature including his recent publication in Viruses late last year. Importantly, Alex highlights some of the implications and challenges we face with developing a neutralising antibody vaccine against HCV.


Induction of a protective immune response against many of the RNA viruses that circulate with large genetic diversity has been problematic. Recent evidence has suggested that a vaccine able to elicit broadly neutralising antibodies (BnAbs) will be met with the most success. This presentation focuses on the role of BnAbs in HCV infection along with the implications and challenges we face with vaccine design.