Dr Maria Rebelo – Investigation of malaria parasite viability after drug treatment in volunteer infection studies

Event type: 
Seminar
Event date: 
Tuesday, 28 May 2019 - 1:00pm to 2:00pm
Location: 
Berg Family Foundation Seminar Room, Level 6, Wallace Wurth Building, Kensington Campus
Contact for inquiries: 
Rata Joseph, +61 (2) 9385 0900 or recpt@kirby.unsw.edu.au
Booking deadline: 

Kirby Institute Seminar Series presents

Dr Maria Rebelo

Dr Maria Rebelo

Post-doctoral Research Scientist, QIMR Berghofer Medical Research Institute

I have always been interested in investigating novel tools or approaches to fight antimalarial drug resistance. During my PhD, I developed a novel drug assay based on the flow cytometric detection of haemozoin to assess antimalarial drug effects. Currently, I am investigating the parasite response to novel antimalarial drug candidates in malaria volunteer infection studies.

Abstract

We developed a novel approach to investigate the viability of malaria parasites in humans after drug treatment. We found that parasite viability may play a critical role in the context of antimalarial drug development, by improving the prediction of drug efficacy and resistance. Thus, assessment of parasite viability after drug treatment should be included as a standard component in antimalarial drug testing clinical trials.

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