Kirby Institute Seminar Series presents
Head, Clinical Retrovirology Section, National Cancer Institute, USA
About your speaker
Dr Frank Maldarelli heads the Clinical Retrovirology Section at the National Cancer Institute, which develops and implements clinical protocols to elucidate mechanisms underlying the emergence of HIV drug resistance in vivo, the dynamics of infection under treatment, and the role of resistance mutations in the efficacy and failure of subsequent treatments. Representing the clinical research arm of the HIV Dynamics and Replication Program (HIV DRP), Dr Maldarelli is an Attending Physician in the NIH NIAID/CCMD HIV Clinic and has established extensive collaborations between the HIV DRP in Frederick and both the NCI HIV and AIDS Malignancy Branch and the NIAID HIV clinical research program in Bethesda.
Antiretroviral therapy controls, but does not cure HIV infection and is associated with long term toxicity. A better understanding of the sources and mechanisms of HIV persistence will lead to testable strategies to eradicate or control HIV. I am looking forward to presenting recent work investigating the persistence and clonal expansion of HIV infected cells during antiretroviral therapy in blood and tissue compartments.