Professor Graeme Meintjes – Addressing challenges in the diagnosis and management of HIV-associated tuberculosis

Event type: 
Seminar
Event date: 
Thursday, 27 September 2018 - 1:00pm to 2:00pm
Location: 
Berg Family Foundation Seminar Room, Level 6, Wallace Wurth Building, Kensington Campus, UNSW Sydney
Contact for bookings: 
Rata Joseph, +61 (2) 9385 0900 or recpt@kirby.unsw.edu.au
Booking deadline: 
Tuesday, 25 September 2018 - 5:00pm

A catered lunch will be provided at 12:30pm. Please RSVP to recpt@kirby.unsw.edu.au by 5pm Tuesday 25 September.

Kirby Institute Seminar Series presents

Professor Graeme Meintjes

Professor Graeme Meintjes

Infectious Diseases Physician, Professor of Medicine and SARChI Chair of Poverty-related Infections, University of Cape Town

About your speaker

Graeme Meintjes is an Infectious Diseases Physician and Professor of Medicine and SARChI Chair of Poverty-related Infections at the University of Cape Town. His research focuses on the clinical conditions affecting patients with advanced HIV disease including disseminated HIV-associated tuberculosis, the tuberculosis-associated immune reconstitution inflammatory syndrome (TB-IRIS) and cryptococcal meningitis. He has been the PI or local PI of several clinical trials and conducts observational cohort studies that address questions related to disease pathogenesis.

Abstract

Around 10% of those who develop tuberculosis (TB) disease globally are HIV co-infected; among those who die from TB, 22% are HIV co-infected. Southern Africa is most severely affected by this co-epidemic. Diagnosis of HIV-associated TB is challenging and delays in diagnosis contribute to mortality. After patients start treatment, complications such as TB-IRIS and drug reactions may occur, and many deaths still occur particularly in patients hospitalised at the time of TB diagnosis. In this presentation, I will discuss our research that has provided novel insights into approaches to diagnosing TB in HIV-infected individuals admitted to hospital that include urine-based assays, the pathogenesis of TB-IRIS, prednisone for prevention of TB-IRIS, and the factors contributing to mortality in those hospitalised with HIV-associated TB.

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