Ms Thiruni Adikari

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Ms Thiruni Adikari

PhD Student

Immunovirology and Pathogenesis Program

tadikari@kirby.unsw.edu.au

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Bio:

Thiruni joined the Viral Immunology Systems Program in August, 2018 and currently reading for her PhD. Her project seeks to understand adaptive immune response to viral infections with a systems approach. Her interest in T cells responses to viral infections started when she was doing research on the pathogenesis of Dengue for her MPhil. Her PhD project will further expand the current understanding of the dynamics of T cells in dengue viral infection by employing a systems approach that integrates molecular biology techniques, single cell technologies, flow cytometry and computational biology and bioinformatics. Findings of this project will potentially contribute towards for a better effector mechanism in a potential vaccine against dengue.

Qualifications:

MPhil

BSc (Honours)

Awards:

President’s Award for Scientific Publication, Sri Lanka- 2015

National Research Council Merit Award for Scientific Publication, Sri Lanka - 2014

International Excellence Award, Eastern Illinois University, USA - 2010

Dean't List, Eastern Illinois University, USA (2011, 2012)

Research

Research activities:

Journal Publications

1. Adikari T.N., Gomes L., Wickramasinghe N., Salimi M., Wijesiriwardana N., Kamaladasa A., Shyamali N.L.A., Ogg G.S. and Malavige G.N. Dengue NS1 antigen contributes to disease severity by inducing IL-10 by monocytes. Journal of Clinical and Experimental Immunology. 2016 Apr;184(1):90-100. doi: 10.1111/cei.12747

2. Kamaladasa, A., Wickramasinghe, N., Adikari, T. N., Gomes, L., Shyamali N.L.A., Salio M., Cerundolo V., Ogg G.S. and Malavige G.N. Expansion of highly activated iNKT cells with altered phenotype in acute dengue infection. Journal of Clinical and Experimental Immunology. 2016 Feb; DOI: 10.1111/cei.12778

3. Jeewandara C., Adikari T.N., Gomes L., Fernando S., Fernando R.H., Perera M.K.T., … Malavige G.N. (2015). Functionality of Dengue Virus Specific Memory T Cell Responses in Individuals Who Were Hospitalized or Who Had Mild or Subclinical Dengue Infection. PLoS Neglected Tropical Diseases, 9(4), e0003673. http://doi.org/10.1371/journal.pntd.0003673

4. Paranavitane, S. A., Gomes, L., Kamaladasa, A., Adikari, T. N., Wickramasinghe, N., Jeewandara, C., … Malavige, G. N. (2014). Dengue NS1 antigen as a marker of severe clinical disease. BMC Infectious Diseases, 14(1), 570. http://doi.org/10.1186/s12879- 014-0570-8

Research Activity Links:

ResearchGate

Google Scholar

Teaching & Supervision

I am available to supervise:

Social Media

LinkedIn:

https://lk.linkedin.com/in/thiruni-adikari-057483142

Events

Jan 31

Professor Jake Baum – Paratechnology: New tools for malaria control and eradication

Dec 12

Professor Mark Jit – Assessing the value of COVID-19 vaccines - a health economics perspective

Dec 06

Professor Anthony Kelleher & Professor Andrew Lloyd – H2Seq: Viral genomics for public health interventions in HIV...

Publications

Journal articles

Conference Papers

Jayaratne HE; Wickramasinghe N; Adikari TN; Gomes L; Kamaladasa A; Ogg GS; Malavige GN, 2016, 'Expansion of regulatory T cells in acute dengue infection does not associate with disease severity', in INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, ELSEVIER SCI LTD, pp. 439 - 439, http://dx.doi.org/10.1016/j.ijid.2016.02.932

Adikari TN; Kamaladasa A; Fernando RH; Fernando SM; Perera TMK; Gomes L; Jayaratne S; Ogg GS; Malavige GN, 2014, 'High CTLA-4 expression in T cells in patients with acute dengue infection', in INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, ELSEVIER SCI LTD, pp. 330 - 330, http://dx.doi.org/10.1016/j.ijid.2014.03.1101

Preprints

Louie RHY; Cai C; Singh M; Deveson I; Ferguson J; Amos TG; McGuire HM; Samir J; Gowrishankar K; Adikari T; Balderas R; Bishop D; Gottlieb D; Blyth E; Micklethwaite K; Luciani F, 2022, CAR⁺ and CAR^- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion, http://dx.doi.org/10.1101/2022.03.29.22273013

Louie R; Cai C; Singh M; Deveson I; Ferguson J; Amos T; McGuire H; Samir J; Gowrishankar K; Adikari T; Balderas R; Bishop D; Gottlieb D; Blyth E; Micklethwaite K; Luciani F, 2022, CAR+ and CAR- T cells differentiate into an NK-like subset that is associated with increased inflammatory cytokines following infusion, http://dx.doi.org/10.21203/rs.3.rs-1495587/v1

Cai C; Samir J; Pirozyan M; Adikari T; Gupta M; Leung P; Hughes B; Van der Byl W; Rizzetto S; Elthala A; Keoshkerian E; Palgen J-L; Peters T; Nguyen T; Louie R; Kedzierska K; Gaudieri S; Bull R; Lloyd A; Luciani F, 2021, Single cell multi-omics reveals early elevated function and multiple fates within human progenitor exhausted CD8⁺ T cells, http://dx.doi.org/10.1101/2021.09.09.459584

Tennant E; Figtree M; Tallon J; Bull RA; Yeang M; Deveson IW; Ferguson JM; Adikari T; Holmes EC; Hal SV; Hammond JM; Stevanovski I; Mitsakos K; Hilditch-Roberts D; Rawlinson W; Hudson B, 2021, Epidemiological and Genomic analysis of a Sydney Hospital COVID-19 Outbreak, http://dx.doi.org/10.1101/2021.02.17.21251943

Bull RA; Adikari T; Ferguson JM; Hammond JM; Stevanovski I; Beukers AG; Naing Z; Yeang M; Verich A; Gamaarachchi H; Kim KW; Luciani F; Stelzer-Braid S; Eden J-S; Rawlinson WD; van Hal SJ; Deveson IW, 2020, Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis, http://dx.doi.org/10.1101/2020.08.04.236893

Ms Thiruni Adikari

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Events

Publications

Journal articles

Conference Papers

Preprints