Dr Raymond Louie

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Dr Raymond Louie

Postdoctoral Researcher

Immunovirology and Pathogenesis Program

rlouie@kirby.unsw.edu.au

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Bio:

Raymond Louie received a PhD in Electrical Engineering at the University of Sydney, after which he was an ARC Postdoctoral Fellow focusing on wireless communications. He then moved to the Hong Kong University of Science and Technology, where he focused on applying statistical and machine learning tools to viral sequence data, to aid in the design of effective vaccines. His current research is now applying statistical and machine learning tools to single cell data, with a focus on immunological data.

Qualifications:

PhD. in Electrical Engineering, University of Sydney, Australia
B.E/B. Sc. in Electrical Engineering/Computer Science (1^st Class Honours), University of New South Wales, Australia

Grants:

Hong Kong Research Grants Council General Research Fund, Chief (Primary) Investigator (2017-2019)
- “Statistical inference of the fitness parameters driving viral evolution using time series data”, HKD 482,605 (AUD 77,168.32)
Hong Kong Research Grants Council General Research Fund, Chief (Primary) Investigator (2016-2018),
- “A novel statistical inference framework for big data applications: Identifying hidden multi-variate non-linear associations”, HKD 696,029 (AUD 111,294.72)
Australian Research Council Discovery Project grant, Chief (and sole) Investigator (2011-2013).
- “Design of future cognitive radio relay networks”. AUD 255,000

Keywords:

statistical analysis

machine learning

bioinformatics

Research

Research activities:

Journal Papers (Computational biology)

S. Sohail*, R. H. Y. Louie*, J. P. Barton, and M. R. McKay, “MPL resolves genetic linkage in fitness inference from complex evolutionary histories”, Nature Biotechnology, November 2020. *Equal contribution
A. A. Quadeer, M. R. McKay, J.P. Barton, R.H.Y. Louie, “MPF-BML: a standalone GUI-based package for maximum entropy model inference”, Bioinformatics, 36 (7), pp 2278-2279, April, 2020
A. A. Quadeer, R.H.Y. Louie and M. R. McKay, "Identifying immunologically-vulnerable regions of the HCV E2 glycoprotein and broadly neutralizing antibodies that target them”, Nature Communications, 10 (1), pp. 1-11, 2019
R. H. Y. Louie, K. J. Kaczorowski, J. P. Barton, A. K. Chakraborty, and M. R. McKay, “The fitness landscape of the human immunodeficiency virus envelope proteins that are the targets of humoral immune responses”, Proceedings of the National Academy of Sciences of the USA (PNAS), 115:E564-E573, Jan 2018.
A. A. Quadeer, R.H.Y. Louie, K. Shekhar, A. K. Chakraborty, I. Hsing, and M. R. McKay, “Statistical linkage of mutations in the non-structural proteins of Hepatitis C virus exposes targets for immunogen design,” Journal of Virology, vol. 88, no. 13, pp. 7628-7644, July 2014

Journal Papers (Application of signal processing, information theory, game theory, optimization, probability and statistical tools to wireless communication systems)

Y. Wu, R. H. Y. Louie, M. R. McKay, “Asymptotic outage probability of MIMO-MRC systems in double-correlated Rician environments”, IEEE Transactions on Wireless Communications, vol. 15, no. 1, pp. 367-376, Jan. 2016
D. M. Jimenez, R.H.Y. Louie, M. R. McKay, and Y. Chen, “Analysis and design of multiple-antenna cognitive radios with multiple primary user signals”, IEEE Transactions on Signal Processing, vol. 63, no. 18, pp. 492954939, September 2015
R.H.Y. Louie, W. Hardjawana, Y. Li and B. Vucetic, “Distributed multiple-access for smart grid home area networks: Compressed sensing with multiple antennas”, IEEE Transactions on Smart Grid, vol. 5, no. 6, pp. 2938-2946, November 2014
S. Bayat, R.H.Y. Louie, Z. Han, B. Vucetic and Y. Li, "Distributed user association and femtocell allocation in heterogeneous wireless networks,” IEEE Transactions on Communications¸ vol. 62, no. 8, pp. 3027-3043, August 2014.
H. Chen, Y. Li, R.H.Y. Louie and B. Vucetic, "Autonomous demand side management with instantaneous load billing: an aggregative game approach,” IEEE Transactions on Smart Grid, vol. 7, no. 4, pp. 1744-1754, April 2014
S. Bayat, R.H.Y. Louie, Z. Han, B. Vucetic and Y. Li, "Physical layer security in distributed wireless networks using matching theory,” IEEE Transactions on Information Forensics and Security¸ vol. 8, no. 5, pp. 717-732, May 2013.
S. Bayat, R. H. Y. Louie, B. Vucetic, Y. Li, “Dynamic decentralised algorithms for cognitive radio relay networks with multiple primary and secondary users utilising matching theory”, Trans. Emerging Telecommunications Technologies vol. 24, no. 5, pp. 486-502, 2013
Y. Wu, R.H.Y. Louie and M. R. McKay, “Analysis and design of wireless ad hoc networks with channel estimation errors”, IEEE Transactions on Signal Processing¸ vol. 61, no. 6, pp. 1447-1459, March 2013.
Y. Wu, R.H.Y. Louie, M. R. McKay and I. B. Collings, “Generalized framework for the analysis of linear MIMO transmission schemes in decentralized wireless ad hoc networks”, IEEE Transactions on Wireless Communications¸ vol. 11, no. 8, pp. 2815-27, August 2012.
R. Manna, R.H.Y. Louie, Y. Li and B. Vucetic, “Cooperative spectrum sharing in cognitive radio networks with multiple antennas”, IEEE Transactions on Signal Processing¸ vol. 59, no. 11, pp. 5509-22, November 2011.
R.H.Y. Louie, M.R. McKay, and I.B. Collings, “Open-loop diversity and multiplexing communications in ad hoc networks”, IEEE Transactions on Information Theory, vol. 57, no. 1, pp. 317-344, January 2011.
Y. Li , R.H.Y. Louie and B. Vucetic, “Relay selection with network coding in two-way relay channels”, IEEE Transactions on Vehicular Technology, vol. 59, no. 9, pp. 4489-99, November 2010
M. Elkhashlan, P.L. Yeoh, R.H.Y. Louie and I.B. Collings, “On the exact and asymptotic SER of receive diversity with multiple amplify-and-forward relays” IEEE Transactions on Vehicular Technology, vol. 59, no. 9, pp. 4602-08, November 2010
R.H.Y. Louie, Y. Li and B. Vucetic, “Practical physical layer network coding for two way relay channels: performance analysis and comparison”, IEEE Transactions on Wireless Communications¸ vol. 9, no. 1, pp. 764–77, February 2010.
R.H.Y. Louie, Y. Li and B. Vucetic, “Zero forcing in general two-hop relay networks”, IEEE Transactions on Vehicular Technology, vol. 59, no. 1, pp. 191–202, January 2010.
R.H.Y. Louie, M.R. McKay, and I.B. Collings, “Maximum sum-rate of MIMO multiuser scheduling with linear receivers”, IEEE Transactions on Communications, vol. 57, no. 11, pp. 3500–10, November 2009.
R.H.Y. Louie, M.R. McKay, and I.B. Collings, “New performance results for multiuser optimum combining in the presence of Rician fading”, IEEE Transactions on Communications, vol. 57, no. 8, pp. 2348–58, 2009.
R.H.Y. Louie, Y. Li, H. Suraweera and B. Vucetic, “Performance analysis of beamforming in two hop amplify and forward relay networks with antenna correlation”, IEEE Transactions on Wireless Communications, vol. 8, no. 6, pp. 3132–41, 2009.
H. Suraweera , R.H.Y. Louie, Y. Li, George K. Karagiannidis, and B. Vucetic, “Two hop amplify-and-forward transmission in mixed Rayleigh and Rician channels”, IEEE Communications Letters, vol. 13, no. 4, pp. 227–29, 2009.
R.H.Y. Louie, M.R. McKay, and I.B. Collings, “Impact of correlation on the capacity of multiple access and broadcast channels with MIMO-MRC”, IEEE Transactions on Wireless Communications, vol. 7, no. 6, pp. 2397–2407, 2008.

Media Coverage

Media coverage includes (see http://www.mckayspcb.com/news/ for a complete list of >20 media articles)

SCMP - Breakthrough HKUST-led research on mapping of HIV weak spots paves way for vaccine
- http://www.scmp.com/news/hong-kong/health-environment/article/2132436/br...
RTHK - Hong Kong Today (Big data analysis helping in development of HIV vaccine)
- http://news.rthk.hk/rthk/en/news-programmes/this-episode.htm?cmsid=77&ep...
Eurekalert – Big data methods learn the fitness landscape of the HIV envelope protein
- https://eurekalert.org/pub_releases/2018-02/hkuo-bdm020618.php

Socio-economic Objective (SEO) tags:

Infectious Diseases

Expanding Knowledge in the Mathematical Sciences

Teaching & Supervision

Teaching:

ELEC2100H Honors – Signals and Systems (HKUST)
- Fall 2015, 2016, 2017 (full course)
ELEC5450 – Random Matrix Theory and Applications (HKUST)
- 8/3/2017, 15/3/2017, 16/3/2018 (guest lecturer)
BIEN5040 – Introduction to Bioengineering Research (HKUST)
- 23/9/2015, 30/9/2015, 7/10/2016 (guest lecturer)
ELEC2600 - Probability and Random Processes in Engineering (HKUST)
- Fall 2014 (full course)
- 8/11/2013 (guest lecturer)
ELEC5507 – Error Control Coding (University of Sydney)
- 2010-2012 (full course)

Events

Nov 16

Dr Sarah Sasson – Local villains: Tissue Resident Memory T cells in Checkpoint Inhibitor Colitis

Nov 02

Kirby Institute Postgraduate Student Prize 2021: Miss Heather Valerio

Oct 26

Professor John Kaldor – Global health research at the Kirby Institute: A brief history and future prospects

Publications

Journal articles

Louie RHY; Kaczorowski KJ; Barton JP; Chakraborty AK; McKay MR, 2018, 'Fitness landscape of the human immunodeficiency virus envelope protein that is targeted by antibodies', Proceedings of the National Academy of Sciences of the United States of America, vol. 115, pp. E564 - E573, http://dx.doi.org/10.1073/pnas.1717765115

Wu Y; Louie RHY; McKay MR, 2016, 'Asymptotic Outage Probability of MIMO-MRC Systems in Double-Correlated Rician Environments', IEEE Transactions on Wireless Communications, vol. 15, pp. 367 - 376, http://dx.doi.org/10.1109/TWC.2015.2473167

Morales-Jimenez D; Louie RHY; McKay MR; Chen Y, 2015, 'Analysis and Design of Multiple-Antenna Cognitive Radios with Multiple Primary User Signals', IEEE Transactions on Signal Processing, vol. 63, pp. 4925 - 4939, http://dx.doi.org/10.1109/TSP.2015.2448528

Louie RHY; Hardjawana W; Li Y; Vucetic B, 2014, 'Distributed multiple-access for smart grid home area networks: Compressed sensing with multiple antennas', IEEE Transactions on Smart Grid, vol. 5, pp. 2938 - 2946, http://dx.doi.org/10.1109/TSG.2014.2320925

Bayat S; Louie RHY; Han Z; Vucetic B; Li Y, 2014, 'Distributed user association and femtocell allocation in heterogeneous wireless networks', IEEE Transactions on Communications, vol. 62, pp. 3027 - 3043, http://dx.doi.org/10.1109/TCOMM.2014.2339313

Chen H; Li Y; Louie RHY; Vucetic B, 2014, 'Autonomous demand side management based on energy consumption scheduling and instantaneous load billing: An aggregative game approach', IEEE Transactions on Smart Grid, vol. 5, pp. 1744 - 1754, http://dx.doi.org/10.1109/TSG.2014.2311122

Quadeer AA; Louie RHY; Shekhar K; Chakraborty AK; Hsing IM; McKay MR, 2014, 'Statistical linkage analysis of substitutions in patient-derived sequences of genotype 1a Hepatitis C virus nonstructural protein 3 exposes targets for immunogen design', Journal of Virology, vol. 88, pp. 7628 - 7644, http://dx.doi.org/10.1128/JVI.03812-13

Bayat S; Louie RHY; Han Z; Vucetic B; Li Y, 2013, 'Physical-layer security in distributed wireless networks using matching theory', IEEE Transactions on Information Forensics and Security, vol. 8, pp. 717 - 732, http://dx.doi.org/10.1109/TIFS.2013.2251335

Wu Y; Louie RHY; McKay MR, 2013, 'Analysis and design of wireless ad hoc networks with channel estimation errors', IEEE Transactions on Signal Processing, vol. 61, pp. 1447 - 1459, http://dx.doi.org/10.1109/TSP.2012.2237167

Bayat S; Louie RHY; Vucetic B; Li Y, 2013, 'Dynamic decentralised algorithms for cognitive radio relay networks with multiple primary and secondary users utilising matching theory', Transactions on emerging telecommunications technologies, vol. 24, pp. 486 - 502, http://dx.doi.org/10.1002/ett.2663

Wu Y; Louie RHY; McKay MR; Collings IB, 2012, 'Generalized framework for the analysis of linear MIMO transmission schemes in decentralized wireless ad hoc networks', IEEE Transactions on Wireless Communications, vol. 11, pp. 2815 - 2827, http://dx.doi.org/10.1109/TWC.2012.051712.110840

Manna R; Louie RHY; Li Y; Vucetic B, 2011, 'Cooperative spectrum sharing in cognitive radio networks with multiple antennas', IEEE Transactions on Signal Processing, vol. 59, pp. 5509 - 5522, http://dx.doi.org/10.1109/TSP.2011.2163068

Louie RHY; McKay MR; Collings IB, 2011, 'Open-loop spatial multiplexing and diversity communications in ad hoc networks', IEEE Transactions on Information Theory, vol. 57, pp. 317 - 344, http://dx.doi.org/10.1109/TIT.2010.2090222

Elkashlan M; Yeoh PL; Louie RHY; Collings IB, 2010, 'On the exact and asymptotic ser of receive diversity with multiple amplify-and-forward relays', IEEE Transactions on Vehicular Technology, vol. 59, pp. 4602 - 4608, http://dx.doi.org/10.1109/TVT.2010.2076306

Li Y; Louie RHY; Vucetic B, 2010, 'Relay selection with network coding in two-way relay channels', IEEE Transactions on Vehicular Technology, vol. 59, pp. 4489 - 4499, http://dx.doi.org/10.1109/TVT.2010.2070817

Louie RHY; Li Y; Vucetic B, 2010, 'Practical physical layer network coding for two-way relay channels: Performance analysis and comparison', IEEE Transactions on Wireless Communications, vol. 9, pp. 764 - 777, http://dx.doi.org/10.1109/TWC.2010.02.090314

Louie RHY; Li Y; Vucetic B, 2010, 'Zero forcing in general two-hop relay networks', IEEE Transactions on Vehicular Technology, vol. 59, pp. 191 - 202, http://dx.doi.org/10.1109/TVT.2009.2026481

Louie RHY; McKay MR; Collings IB, 2009, 'Maximum sum-rate of mimo multiuser scheduling with linear receivers', IEEE Transactions on Communications, vol. 57, pp. 3500 - 3510, http://dx.doi.org/10.1109/TCOMM.2009.11.080210

Louie RHY; McKay MR; Collings IB, 2009, 'New performance results for multiuser optimum combining in the presence of rician fading', IEEE Transactions on Communications, vol. 57, pp. 2348 - 2358, http://dx.doi.org/10.1109/TCOMM.2009.08.070412

Louie RHY; Li Y; Suraweera HA; Vucetic B, 2009, 'Performance analysis of beamforming in two hop amplify and forward relay networks with antenna correlation', IEEE Transactions on Wireless Communications, vol. 8, pp. 3132 - 3141, http://dx.doi.org/10.1109/TWC.2009.080807

Suraweera HA; Louie RHY; Li Y; Karagiannidis GK; Vucetic B, 2009, 'Two hop amplify-and-forward transmission in mixed Rayleigh and Rician fading channels', IEEE Communications Letters, vol. 13, pp. 227 - 229, http://dx.doi.org/10.1109/LCOMM.2009.081943

Louie RHY; McKay MR; Collings TB, 2008, 'Impact of correlation on the capacity of multiple access and broadcast channels with MIMO-MRC', IEEE Transactions on Wireless Communications, vol. 7, pp. 2397 - 2407, http://dx.doi.org/10.1109/TWC.2008.070126

Conference Papers

Louie RHY; Hardjawana W; Li Y; Vucetic B, 2012, 'Distributed multiple-access for wireless communications: Compressed sensing with multiple antennas', in GLOBECOM - IEEE Global Telecommunications Conference, pp. 3622 - 3627, http://dx.doi.org/10.1109/GLOCOM.2012.6503678

Bayat S; Louie RHY; Han Z; Li Y; Vucetic B, 2012, 'Multiple operator and multiple femtocell networks: Distributed stable matching', in IEEE International Conference on Communications, pp. 5140 - 5145, http://dx.doi.org/10.1109/ICC.2012.6363955

Bayat S; Louie RHY; Li Y; Ng SX; Vucetic B, 2012, 'Distributed algorithm for multiple antenna cooperative cognitive radio networks with multiple primary and secondary users', in Progress in Electromagnetics Research Symposium, pp. 297 - 302

Wu Y; Louie RHY; McKay MR, 2012, 'Impact of training on the transmission capacity of wireless ad hoc networks', in ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, pp. 3133 - 3136, http://dx.doi.org/10.1109/ICASSP.2012.6288579

Bayat S; Louie RHY; Han Z; Li Y; Vucetic B, 2012, 'Distributed stable matching algorithm for physical layer security with multiple source-destination pairs and jammer nodes', in IEEE Wireless Communications and Networking Conference, WCNC, pp. 2688 - 2693, http://dx.doi.org/10.1109/WCNC.2012.6214256

Louie RHY; McKay MR; Jindal N; Collings IB, 2011, 'Spatial multiplexing with MMSE receivers in ad hoc networks', in IEEE International Conference on Communications, http://dx.doi.org/10.1109/icc.2011.5963372

Bayat S; Louie RHY; Li Y; Vucetic B, 2011, 'Cognitive radio relay networks with multiple primary and secondary users: Distributed stable matching algorithms for spectrum access', in IEEE International Conference on Communications, http://dx.doi.org/10.1109/icc.2011.5962935

Wu Y; Louie RHY; McKay MR; Collings IB, 2010, 'MIMO beamforming with quantized feedback in ad hoc networks: Transmission capacity analysis', in Conference Record - Asilomar Conference on Signals, Systems and Computers, pp. 1582 - 1587, http://dx.doi.org/10.1109/ACSSC.2010.5757804

Wu Y; Louie RHY; McKay MR; Collings IB, 2010, 'Benefits of transmit antenna selection in ad hoc networks', in GLOBECOM - IEEE Global Telecommunications Conference, http://dx.doi.org/10.1109/GLOCOM.2010.5684289

Manna R; Louie RHY; Li Y; Vucetic B, 2010, 'Cooperative amplify-and-forward relaying in cognitive radio networks', in 2010 Proceedings of the 5th International Conference on Cognitive Radio Oriented Wireless Networks and Communications, CROWNCom 2010, http://dx.doi.org/10.4108/ICST.CROWNCOM2010.9260

Elkashlan M; Yeoh PL; Louie RHY; Collings IB, 2010, 'Exact and asymptotic SER of receive diversity in multiple amplify-and-forward relaying', in IEEE International Conference on Communications, http://dx.doi.org/10.1109/ICC.2010.5501920

Manna R; Louie RHY; Li Y; Vucetic B, 2010, 'Interference cancellation in two hop multiuser cognitive radio networks', in IEEE Wireless Communications and Networking Conference, WCNC, http://dx.doi.org/10.1109/WCNC.2010.5506446

Elkashlan M; Yeoh PL; Louie RHY; Collings IB, 2010, 'SER of multiple fixed gain amplify-and-forward relays with receive diversity', in IEEE Vehicular Technology Conference, IEEE, presented at 2010 IEEE 71st Vehicular Technology Conference, 16 May 2010 - 19 May 2010, http://dx.doi.org/10.1109/VETECS.2010.5494035

Louie RHY; Li Y; Vucetic B, 2009, 'Performance analysis of physical layer network coding in two-way relay channels', in GLOBECOM - IEEE Global Telecommunications Conference, http://dx.doi.org/10.1109/GLOCOM.2009.5426193

Louie RHY; McKay MR; Collings IB, 2009, 'Spatial multiplexing with MRC and ZF receivers in ad hoc networks', in IEEE International Conference on Communications, http://dx.doi.org/10.1109/ICC.2009.5199472

Louie RHY; Li Y; Vucetic B, 2009, 'Zero forcing processing in two hop networks with multiple source, relay and destination nodes', in IEEE International Conference on Communications, http://dx.doi.org/10.1109/ICC.2009.5199577

Louie RHY; Li Y; Suraweera HA; Vucetic B, 2009, 'Beamforming with antenna correlation in two hop amplify and forward relay networks', in IEEE Wireless Communications and Networking Conference, WCNC, http://dx.doi.org/10.1109/WCNC.2009.4917612

Louie RHY; McKay MR; Collings IB, 2008, 'Sum Capacity of Opportunistic Scheduling for Multiuser MIMO Systems with Linear Receivers', in GLOBECOM - IEEE Global Telecommunications Conference, pp. 3724 - 3728, http://dx.doi.org/10.1109/GLOCOM.2008.ECP.715

Louie RHY; McKay MR; Collings IB, 2008, 'New asymptotic performance results for MIMO and SIMO optimum combining', in Proceedings of the 2008 Australian Communications Theory Workshop, AusCTW08, pp. 69 - 74, http://dx.doi.org/10.1109/AUSCTW.2008.4460824

Louie RHY; McKay MR; Collings IB, 2008, 'optimum combining systems in the presence of Rician fading: SINR and capacity analysis', in ICASSP, IEEE International Conference on Acoustics, Speech and Signal Processing - Proceedings, pp. 2745 - 2748, http://dx.doi.org/10.1109/ICASSP.2008.4518217

Louie RHY; McKay MR; Collings IB, 2008, 'Optimum combining in Rician fading: Performance analysis in asymptotic SNR regimes', in IEEE International Conference on Communications, pp. 850 - 854, http://dx.doi.org/10.1109/ICC.2008.167

Louie RHY; Li Y; Vucetic B, 2008, 'Performance analysis of beamforming in two hop amplify and forward relay networks', in IEEE International Conference on Communications, pp. 4311 - 4315, http://dx.doi.org/10.1109/ICC.2008.809

Louie RHY; McKay MR; Collings IB, 2008, 'On the use of multiple antennas to reduce MAC layer coordination in Ad hoc networks', in IEEE International Conference on Communications, pp. 4554 - 4558, http://dx.doi.org/10.1109/ICC.2008.854

Louie RHY; McKay MR; Collings IB, 2007, 'Capacity increase with antenna correlation for multiuser MIMO-MRC', in 8th Australian Communication Theory Workshop, AusCTW 2007, pp. 139 - 143

Louie RHY; McKay MR; Collings IB; Vucetic B, 2007, 'Capacity approximations for multiuser MIMO-MRC with antenna correlation', in IEEE International Conference on Communications, pp. 5195 - 5200, http://dx.doi.org/10.1109/ICC.2007.859

Louie RHY; Collings IB; McKay MR, 2007, 'Analysis of dense ad hoc networks with spatial diversity', in GLOBECOM - IEEE Global Telecommunications Conference, pp. 1253 - 1257, http://dx.doi.org/10.1109/GLOCOM.2007.241

Dr Raymond Louie

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