I am an early career researcher studying viral evolution of RNA viruses, in particular, hepatitis C virus, norovirus and influenza. I have been investigating the viral and host factors that different RNA viruses use to generate diversity and maintain their survival in the population. We take an interdisciplinary approach involving cutting edge virological, immunological and bioinformatic techniques. Our contribution to virology ranges from the development of virological in vitro based fitness assays, viral gene expression studies, molecular epidemiology, evolutionary analysis of adaptive immune responses against RNA viruses, and bioinformatics. A recent research focus has been the analysis of over 30 million nucleotides generated through next generation sequencing approaches in a longitudinal study of ten HCV infected patients (Bull, Luciani et al. PLoS pathogens 2011).
Major Research Interests
- Within-host evolutionary dynamics of RNA viruses including HCV, influenza, and NoV
- Investigating the selective pressures of cellular and humoral immune responses against HCV
- NHMRC Training Postdoctoral Research Fellow, School of Medical Sciences, University of New South Wales, UNSW. 2010 – continuing.
- Visiting Research Scientist, Stanford University, USA. 2011
- Postdocotoral Research Fellow in Microbiology and Molecular Biology, University of New South Wales, UNSW. 2007 - 2010
- Visiting Research Fellow, La Trobe University, Australia. 2008
- PhD in 2007 at the University of New South Wales, Australia, in Molecular Biology and funded by an Australian Postgraduate Award.
- Visiting Research Scientist, National Institute of Infectious Diseases, NIID, Tokyo, Japan 2006
- B.Sc (Hons 1st class) in Medical Microbiology and Immunobiology, University of New South Wales, Australia