Dr David Khoury

Aggarwal A; Stella AO; Walker G; Akerman A; Esneau C; Milogiannakis V; Burnett DL; McAllery S; Silva MR; Lu Y; Foster CSP; Brilot F; Pillay A; Van Hal S; Mathivanan V; Fichter C; Kindinger A; Hoppe AC; Munier ML; Amatayakul-Chantler S; Roth N; Coppola G; Symonds GP; Schofield P; Jackson J; Lenthall H; Henry JY; Mazigi O; Jäck HM; Davenport MP; Darley DR; Matthews GV; Khoury DS; Cromer D; Goodnow CC; Christ D; Robosa R; Starck DJ; Bartlett NW; Rawlinson WD; Kelleher AD; Turville SG, 2022, 'Platform for isolation and characterization of SARS-CoV-2 variants enables rapid characterization of Omicron in Australia', Nature Microbiology, vol. 7, pp. 896 - 908, http://dx.doi.org/10.1038/s41564-022-01135-7

Radohery GFR; Gower J; Barber BE; Kansagra K; Möhrle JJ; Davenport MP; McCarthy JS; Khoury DS; Rebelo M, 2022, 'Effect of novel antimalarial ZY-19489 on Plasmodium falciparum viability in a volunteer infection study', The Lancet Infectious Diseases, vol. 22, pp. 760 - 761, http://dx.doi.org/10.1016/S1473-3099(22)00294-8

Goel RR; Painter MM; Lundgreen KA; Apostolidis SA; Baxter AE; Giles JR; Mathew D; Pattekar A; Reynaldi A; Khoury DS; Gouma S; Hicks P; Dysinger S; Hicks A; Sharma H; Herring S; Korte S; KC W; Oldridge DA; Erickson RI; Weirick ME; McAllister CM; Awofolaju M; Tanenbaum N; Dougherty J; Long S; D'Andrea K; Hamilton JT; McLaughlin M; Williams JC; Adamski S; Kuthuru O; Drapeau EM; Davenport MP; Hensley SE; Bates P; Greenplate AR; Wherry EJ, 2022, 'Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine', Cell, vol. 185, pp. 1875 - 1887.e8, http://dx.doi.org/10.1016/j.cell.2022.04.009

Mehra S; Stadler E; Khoury D; McCaw JM; Flegg JA, 2022, 'Hypnozoite dynamics for Plasmodium vivax malaria: The epidemiological effects of radical cure', Journal of Theoretical Biology, vol. 537, pp. 111014, http://dx.doi.org/10.1016/j.jtbi.2022.111014

Cele S; Jackson L; Khoury DS; Khan K; Moyo-Gwete T; Tegally H; San JE; Cromer D; Scheepers C; Amoako DG; Karim F; Bernstein M; Lustig G; Archary D; Smith M; Ganga Y; Jule Z; Reedoy K; Hwa SH; Giandhari J; Blackburn JM; Gosnell BI; Abdool Karim SS; Hanekom W; Davies MA; Hsiao M; Martin D; Mlisana K; Wibmer CK; Williamson C; York D; Harrichandparsad R; Herbst K; Jeena P; Khoza T; Kløverpris H; Leslie A; Madansein R; Magula N; Manickchund N; Marakalala M; Mazibuko M; Moshabela M; Mthabela N; Naidoo K; Ndhlovu Z; Ndung’u T; Ngcobo N; Nyamande K; Patel V; Smit T; Steyn A; Wong E; von Gottberg A; Bhiman JN; Lessells RJ; Moosa MYS; Davenport MP; de Oliveira T; Moore PL; Sigal A, 2022, 'Omicron extensively but incompletely escapes Pfizer BNT162b2 neutralization', Nature, vol. 602, pp. 654 - 656, http://dx.doi.org/10.1038/s41586-021-04387-1

Cromer D; Steain M; Reynaldi A; Schlub TE; Wheatley AK; Juno JA; Kent SJ; Triccas JA; Khoury DS; Davenport MP, 2022, 'Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis', The Lancet Microbe, vol. 3, pp. e52 - e61, http://dx.doi.org/10.1016/S2666-5247(21)00267-6

Goel RR; Painter MM; Apostolidis SA; Mathew D; Meng W; Rosenfeld AM; Lundgreen KA; Reynaldi A; Khoury DS; Pattekar A; Gouma S; Kuri-Cervantes L; Hicks P; Dysinger S; Hicks A; Sharma H; Herring S; Korte S; Baxter AE; Oldridge DA; Giles JR; Weirick ME; McAllister CM; Awofolaju M; Tanenbaum N; Drapeau EM; Dougherty J; Long S; D’Andrea K; Hamilton JT; McLaughlin M; Williams JC; Adamski S; Kuthuru O; Frank I; Betts MR; Vella LA; Grifoni A; Weiskopf D; Sette A; Hensley SE; Davenport MP; Bates P; Luning Prak ET; Greenplate AR; John Wherry E, 2021, 'mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern', Science, vol. 374, pp. eabm0829, http://dx.doi.org/10.1126/science.abm0829

Wheatley AK; Juno JA; Wang JJ; Selva KJ; Reynaldi A; Tan HX; Lee WS; Wragg KM; Kelly HG; Esterbauer R; Davis SK; Kent HE; Mordant FL; Schlub TE; Gordon DL; Khoury DS; Subbarao K; Cromer D; Gordon TP; Chung AW; Davenport MP; Kent SJ, 2021, 'Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19', Nature Communications, vol. 12, pp. 1162, http://dx.doi.org/10.1038/s41467-021-21444-5

Rebelo M; McCarthy JS; Khoury DS, 2021, 'Reply to White and Watson', Journal of Infectious Diseases, vol. 224, pp. 739 - 740, http://dx.doi.org/10.1093/infdis/jiaa791

Khoury DS; Cromer D; Reynaldi A; Schlub TE; Wheatley AK; Juno JA; Subbarao K; Kent SJ; Triccas JA; Davenport MP, 2021, 'Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection', Nature Medicine, vol. 27, pp. 1205 - 1211, http://dx.doi.org/10.1038/s41591-021-01377-8

Cromer D; Reynaldi A; Steain M; Triccas J; Davenport M; Khoury D, 2021, 'Relating in vitro neutralisation level and protection in the CVnCoV (CUREVAC) trial', , http://dx.doi.org/10.1101/2021.06.29.21259504

Rebelo M; Pawliw R; Gower J; Webb L; Mitchell H; Pava Z; Watts RE; Davenport MP; McCarthy JS; Khoury DS, 2021, 'Parasite Viability as a Superior Measure of Antimalarial Drug Activity in Humans', Journal of Infectious Diseases, vol. 223, pp. 2154 - 2163, http://dx.doi.org/10.1093/infdis/jiaa678

Cromer D; Juno JA; Khoury D; Reynaldi A; Wheatley AK; Kent SJ; Davenport MP, 2021, 'Prospects for durable immune control of SARS-CoV-2 and prevention of reinfection', Nature Reviews Immunology, vol. 21, pp. 395 - 404, http://dx.doi.org/10.1038/s41577-021-00550-x

Khoury D; Cromer D; Reynaldi A; Schlub T; Wheatley A; Juno J; Subbarao K; Kent S; Triccas J; Davenport M, 2021, 'What level of neutralising antibody protects from COVID-19?', , http://dx.doi.org/10.1101/2021.03.09.21252641

Cromer D; Steain M; Reynaldi A; Schlub T; Wheatley A; Juno J; Kent S; Triccas J; Khoury D; Davenport M, 2021, 'SARS-CoV-2 variants: levels of neutralisation required for protective immunity', , http://dx.doi.org/10.1101/2021.08.11.21261876

Soon MSF; Lee HJ; Engel JA; Straube J; Thomas BS; Pernold CPS; Clarke LS; Laohamonthonkul P; Haldar RN; Williams CG; Lansink LIM; Moreira ML; Bramhall M; Koufariotis LT; Wood S; Chen X; James KR; Lönnberg T; Lane SW; Belz GT; Engwerda CR; Khoury DS; Davenport MP; Svensson V; Teichmann SA; Haque A, 2020, 'Transcriptome dynamics of CD4⁺ T cells during malaria maps gradual transit from effector to memory', Nature Immunology, vol. 21, pp. 1597 - 1610, http://dx.doi.org/10.1038/s41590-020-0800-8

Khoury DS; Wheatley AK; Ramuta MD; Reynaldi A; Cromer D; Subbarao K; O’Connor DH; Kent SJ; Davenport MP, 2020, 'Measuring immunity to SARS-CoV-2 infection: comparing assays and animal models', Nature Reviews Immunology, vol. 20, pp. 727 - 738, http://dx.doi.org/10.1038/s41577-020-00471-1

Khoury DS; Cao P; Zaloumis SG; Davenport MP, 2020, 'Artemisinin Resistance and the Unique Selection Pressure of a Short-acting Antimalarial', Trends in Parasitology, vol. 36, pp. 884 - 887, http://dx.doi.org/10.1016/j.pt.2020.07.004

Corder RM; de Lima ACP; Khoury DS; Docken SS; Davenport MP; Ferreira MU, 2020, 'Quantifying and preventing plasmodium vivax recurrences in primaquine-untreated pregnant women: An observational and modeling study in Brazil', PLoS Neglected Tropical Diseases, vol. 14, pp. 1 - 16, http://dx.doi.org/10.1371/journal.pntd.0008526

Collins KA; Wang CYT; Adams M; Mitchell H; Robinson GJ; Rampton M; Elliott S; Odedra A; Khoury D; Ballard E; Shelper TB; Lucantoni L; Avery VM; Chalon S; Moehrle JJ; McCarthy JS, 2020, 'A Plasmodium vivax experimental human infection model for evaluating efficacy of interventions', Journal of Clinical Investigation, vol. 130, pp. 2920 - 2927, http://dx.doi.org/10.1172/JCI134923

Khoury DS; Zaloumis SG; Grigg MJ; Haque A; Davenport MP; Cromer D; Rebelo M; Cao P; McCaw JM; Simpson JA; Flegg JA; Wilson DW; Anstey NM; McCarthy JS, 2020, 'Malaria Parasite Clearance: What Are We Really Measuring?', Trends in Parasitology, vol. 36, pp. 413 - 426, http://dx.doi.org/10.1016/j.pt.2020.02.005

Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2019, 'Corrigendum: Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration (Journal of Infectious Diseases (2016) 214 (753-761) DOI: 10.1093/infdis/jiw234)', Journal of Infectious Diseases, vol. 219, pp. 1852 - 1853, http://dx.doi.org/10.1093/infdis/jiy729

Akter J; Khoury DS; Aogo R; Lansink LIM; SheelaNair A; Thomas BS; Laohamonthonkul P; Pernold CPS; Dixon MWA; Soon MSF; Fogg LG; Engel JA; Elliott T; Sebina I; James KR; Cromer D; Davenport MP; Haque A, 2019, 'Plasmodium-specific antibodies block in vivo parasite growth without clearing infected red blood cells', PLoS Pathogens, vol. 15, pp. e1007599, http://dx.doi.org/10.1371/journal.ppat.1007599

Davenport MP; Khoury DS; Cromer D; Lewin SR; Kelleher AD; Kent SJ, 2019, 'Functional cure of HIV: the scale of the challenge', Nature Reviews Immunology, vol. 19, pp. 45 - 54, http://dx.doi.org/10.1038/s41577-018-0085-4

Betts M; Kuri Cervantes L; Pampena MB; Samer S; Khoury D; Frank I; Paiardini M; Davenport M; Bar K; Veazey R, 2019, 'Peripheral blood SIV/HIV originates from infected cells in tissues', Journal of Virus Eradication, vol. 5, pp. 27 - 27, http://dx.doi.org/10.1016/s2055-6640(20)30142-4

Zaloumis SG; Cao P; Dini S; Davenport MP; Cromer D; Khoury DS; Fowkes FJI; McCaw JM; Simpson JA, 2018, 'In silico investigation of the decline in clinical efficacy of artemisinin combination therapies due to increasing artemisinin and partner drug resistance', Antimicrobial Agents and Chemotherapy, vol. 62, http://dx.doi.org/10.1128/AAC.01292-18

Aogo RA; Khoury DS; Cromer D; Elliott T; Akter J; Fogg LG; Nair AS; Liligeto UN; Soon MSF; Thomas BS; Pernold CPS; Romanczuk AS; Laohamonthonkul P; Haque A; Davenport MP, 2018, 'Quantification of host-mediated parasite clearance during blood-stage Plasmodium infection and anti-malarial drug treatment in mice', International Journal for Parasitology, vol. 48, pp. 903 - 913, http://dx.doi.org/10.1016/j.ijpara.2018.05.010

Khoury DS; Aogo R; Randriafanomezantsoa-Radohery G; McCaw JM; Simpson JA; McCarthy JS; Haque A; Cromer D; Davenport MP, 2018, 'Within-host modeling of blood-stage malaria', Immunological Reviews, vol. 285, pp. 168 - 193, http://dx.doi.org/10.1111/imr.12697

Khoury DS; Cromer D; Elliott T; Soon MSF; Thomas BS; James KR; Best SE; Aogo RA; Engel JA; Gartlan KH; Akter J; Sebina I; Haque A; Davenport MP, 2017, 'Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo', International Journal for Parasitology, vol. 47, pp. 913 - 922, http://dx.doi.org/10.1016/j.ijpara.2017.05.009

Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, 'A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection', Journal of Theoretical Biology, vol. 430, pp. 117 - 127, http://dx.doi.org/10.1016/j.jtbi.2017.07.017

Khoury DS; Cromer D; Akter J; Sebina I; Elliott T; Thomas BS; Soon MSF; James KR; Best SE; Haque A; Davenport MP, 2017, 'Host-mediated impairment of parasite maturation during blood-stage Plasmodium infection', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, pp. 7701 - 7706, http://dx.doi.org/10.1073/pnas.1618939114

Griffin P; Pasay C; Elliott S; Sekuloski S; Sikulu M; Hugo L; Khoury D; Cromer D; Davenport M; Sattabongkot J; Ivinson K; Ockenhouse C; McCarthy J, 2016, 'Safety and Reproducibility of a Clinical Trial System Using Induced Blood Stage Plasmodium vivax Infection and Its Potential as a Model to Evaluate Malaria Transmission', PLoS Neglected Tropical Diseases, vol. 10, http://dx.doi.org/10.1371/journal.pntd.0005139

Khoury DS; Cromer D; Möhrle JJ; McCarthy JS; Davenport MP, 2016, 'Defining the effectiveness of antimalarial chemotherapy: Investigation of the lag in parasite clearance following drug administration', Journal of Infectious Diseases, vol. 214, pp. 753 - 761, http://dx.doi.org/10.1093/infdis/jiw234

Khoury DS; Cromer D; Best SE; James KR; Sebina I; Haque A; Davenport MP, 2015, 'Reduced erythrocyte susceptibility and increased host clearance of young parasites slows Plasmodium growth in a murine model of severe malaria', Scientific Reports, vol. 5, http://dx.doi.org/10.1038/srep09412

Khoury DS; Cromer D; Best SE; James KR; Kim PS; Engwerda CR; Haque A; Davenport MP, 2013, 'Effect of mature, blood-stage Plasmodium parasite sequestration on pathogen biomass in mathematical and in vivo models of malaria.', Infection and Immunity, vol. 82, pp. 212 - 220, http://dx.doi.org/10.1128/IAI.00705-13

Delaney GW; Khoury D, 2013, 'Onset of rigidity in 3D stretched string networks', European Physical Journal B, vol. 86, http://dx.doi.org/10.1140/epjb/e2012-30445-y

Khoury DS; Barron AB; Myerscough MR, 2013, 'Modelling Food and Population Dynamics in Honey Bee Colonies', PLoS ONE, vol. 8, pp. Article numbere59084, http://dx.doi.org/10.1371/journal.pone.0059084

Khoury DS; Myerscough MR; Barron AB, 2011, 'A quantitative model of honey bee colony population dynamics', PLoS ONE, vol. 6, http://dx.doi.org/10.1371/journal.pone.0018491

Hogan AB; Wu SL; Toor J; Doohan P; Watson OJ; Winskill P; Charles G; Barnsley G; Riley EM; Khoury DS; Ferguson NM; Ghani AC, 2022, Long Term Vaccination Strategies to Mitigate the Global Impact of SARS-CoV-2 Transmission: A Modelling Study, http://dx.doi.org/10.2139/ssrn.4135323

Stadler E; Chai KL; Schlub T; Cromer D; Polizzotto M; Kent S; Beecher C; White H; White H; Turner T; Skoetz N; Skoetz N; Estcourt L; McQuilten Z; Wood E; Khoury D; Davenport M, 2022, Determinants of passive antibody efficacy in SARS-CoV-2 infection, http://dx.doi.org/10.1101/2022.03.21.22272672

Stadler E; Cromer D; Mehra S; Adekunle A; Flegg J; Anstey N; Watson J; Chu C; Mueller I; Robinson L; Schlub T; Davenport M; Khoury D, 2022, Risk of Plasmodium vivax recurrences follows a 30-70 rule and indicates relapse heterogeneity in the population, http://dx.doi.org/10.1101/2022.05.18.22275180

Koutsakos M; Lee WS; Reynaldi A; Tan H-X; Gare G; Kinsella P; Liew KC; Williamson DA; Kent HE; Stadler E; Cromer D; Khoury DS; Wheatley AK; Juno JA; Davenport MP; Kent SJ, 2021, Dynamics of immune recall following SARS-CoV-2 vaccination or breakthrough infection, http://dx.doi.org/10.1101/2021.12.23.21268285

Khoury D; Steain M; Triccas J; Sigal A; Davenport M; Cromer D, 2021, A meta-analysis of Early Results to predict Vaccine efficacy against Omicron, http://dx.doi.org/10.1101/2021.12.13.21267748

Lansink LIM; Engel JA; Lee HJ; Soon MSF; Williams CG; SheelaNair A; Pernold CPS; Laohamonthonkul P; Akter J; Stoll T; Hill MM; Talman AM; Russell A; Lawniczak M; Davenport MP; Khoury DS; Haque A, 2021, Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites, http://dx.doi.org/10.1101/2021.08.18.456784

Mehra S; Stadler E; Khoury D; McCaw JM; Flegg JA, 2021, Hypnozoite dynamics for Plasmodium vivax malaria: the epidemiological effects of radical cure, http://dx.doi.org/10.48550/arxiv.2107.00779

Wheatley AK; Juno JA; Wang JJ; Selva KJ; Reynaldi A; Tan H-X; Shi Lee W; Wragg KM; Kelly HG; Esterbauer R; Davis SK; Kent HE; Mordant FL; Schlub TE; Gordon DL; Khoury DS; Subbarao K; Cromer D; Gordon TP; Chung AW; Davenport MP; Kent SJ, 2020, Evolution of immunity to SARS-CoV-2, http://dx.doi.org/10.1101/2020.09.09.20191205

Soon MSF; Lee HJ; Engel JA; Straube J; Thomas BS; Clarke LS; Laohamonthonkul P; Pernold CPS; Haldar RN; Williams CG; Lansink LIM; Koufariotis R; Lakis V; Wood S; Chen X; James KR; Lönnberg T; Lane SW; Davenport MP; Khoury DS; Svensson V; Teichmann SA; Haque A, 2019, Transcriptome Dynamics Reveals Progressive Transition from Effector to Memory in CD4⁺T cells, http://dx.doi.org/10.1101/675967

Cao P; Klonis N; Zaloumis S; Khoury DS; Cromer D; Davenport MP; Tilley L; Simpson JA; McCaw JM, 2017, A mechanistic model quantifies artemisinin-induced parasite growth retardation in blood-stage Plasmodium falciparum infection, http://dx.doi.org/10.48550/arxiv.1701.05302