Dr Braulio M. Valencia Arroyo

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PhD Student

Viral Immunology Systems Program

barroyo@kirby.unsw.edu.au

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Bio:

Dr. Valencia was born in Cusco, Peru and did medical school at Universidad Peruana Cayetano Heredia (UPCH). Subsequently, he did his postgraduates studies (Research and Clinical training) at The Institute of Tropical Medicine Alexander von Humboldt (IMTAvH), UPCH. During and upon finishing the postgraduate training, he has performed as a clinical researcher at IMTAvH as well as professor of undergraduate and postgraduate courses at UPCH, the University of Alabama at Birmingham, University of California, Irvine, Broward College, and University of Texas Health Science Center at Houston. Dr. Valencia has developed collaborative research with different institutions: the University of Toronto, Drugs for Neglected Diseases initiative (DNDi), Institute of Tropical Medicine Antwerp, Infectious Diseases Research Institute (IDRI), Walter Reed Army Institute of Research, Tulane University, Duke University, and The University of Alabama at Birmingham.

His research interest focused on the point of care diagnostics, clinical trials, vaccine clinical trials and Health Systems Implementation in Neglected Tropical Diseases. In addition to the former, his current research interest is the understanding of immunogenetic determinants of susceptibility and resistance to infectious diseases, particularly Hepatitis C, Epstein-Barr virus, Ross River virus, Coxiella burnetii, and Influenza.

Qualifications:

Infectious Diseases Specialist - Universidad Peruana Cayetano Heredia, Lima, Peru, 2011-2016

Master of Science, Control of Tropical and Infectious Diseases - Universidad Peruana Cayetano Heredia, Lima, Peru, 2009-2011

Medical Doctor (MBBS) - Universidad Peruana Cayetano Heredia, Lima, Peru, 2001-2008

Grants:

2018 - 2022: PhD Scientia Scholarship, UNSW ($40,000 yearly stipend and annual educational fees of $43,440).

2020 - 2021: Postgraduate Research Support Scheme (PRSS) funding for conference travel, UNSW ($ 2,800).

2018 - 2019: Exchange Fellowships for early career researchers, Sydney partnership for health education research and enterprise (SPHERE) ($ 5,000).

2016 - 2017: Gorgas Memorial Foundation Research Grant Award, UAB, USA ($ 27,000).

2015 - 2016: Fogarty Global Health Fellows (Grant 5R25TW009340-04), USA ($ 82,000).

2013 - 2016: Strategic Network on Neglected Tropical Diseases and Zoonoses (SNNDZ), Belgium ($ 52,000).

2011 - 2013: International Society for Infectious diseases small grant (ISID small grant).

Keywords:

severe infectious diseases

genetics and genomics

neglected tropical diseases

next-generation sequencing

Research

Research activities:

Selected peer-review publications (full list available in https://publons.com/researcher/3011676/braulio-markvalencia-arroyo/)

Valencia BM, Lau R, Kariyawasam R, Jara M, et al. Leishmania RNA virus-1 is similarly detected among metastatic and non-metastatic phenotypes in a prospective cohort of American Tegumentary Leishmaniasis. PLoS Negl Trop Dis. 2022 Jan 28;16(1):e0010162. doi: 10.1371/journal.pntd.0010162.

Valencia BM, Lau R, Shao E, Thompson CA, et al. Evaluation of a point-of-care molecular detection device for Leishmania spp. and intercurrent fungal and mycobacterial organisms in Peruvian patients with cutaneous ulcers. Infection. 2021 Aug 8. doi: 10.1007/s15010-021-01673-y.

Valencia BM, Cvejic E, Vollmer-Conna U, Hickie I.B., et al. The severity of the pathogen-induced acute sickness response is affected by polymorphisms in genes of the NLRP3 inflammasome pathway. Brain Behav Immun. 2021 Mar; 93:186-193. doi: 10.1016/j.bbi.2021.01.005.

Adikari TN, Riaz N, Sigera C, Leung P, Valencia BM, et al. Single molecule, near full-length genome sequencing of dengue virus. Sci Rep. 2020 Oct 23;10(1):18196. doi: 10.1038/s41598-020-75374-1.

Saavedra AC, Valencia BM, et al. Ultrasonographic Characteristics of Cutaneous Leishmaniasis. J Eur Acad Dermatol Venereol. 2019 Nov 26 (Epub). doi: 10.1111/jdv.16111.

Barros N, Vasquez N, Woll F, Sanchez C, Valencia B, Llanos-Cuentas A, White AC Jr, Montes M. Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to Leishmania braziliensis. Am J Trop Med Hyg. 2018 Mar;98(3):753-758.

Kariyawasam R, Grewal J, Lau R, Purssell A, Valencia BM, Llanos-Cuentas A, Boggild AK. Influence of Leishmania RNA Virus 1 on Proinflammatory Biomarker Expression in a Human Macrophage Model of American Tegumentary Leishmaniasis. J Infect Dis. 2017 Oct 17;216(7):877-886.

Valencia BM, Jara M, Adaui V, Alba M, Lau R, Arevalo J, Llanos-Cuentas A, Boggild AK. Quantitative Kinetoplast DNA Assessment During Treatment of Mucosal Leishmaniasis as a Potential Biomarker of Outcome: A Pilot Study. Am J Trop Med Hyg. 2016 Jan;94(1):107-13.

Suárez M, Valencia BM, Jara M, Alba M, Boggild AK, Dujardin JC, Llanos-Cuentas A, Arevalo J, Adaui V. Quantification of Leishmania (Viannia) Kinetoplast DNA in Ulcers of Cutaneous Leishmaniasis Reveals Inter-site and Inter-sampling Variability in Parasite Load. PLoS Negl Trop Dis. 2015 Jul 23;9(7):e0003936.

Jara M, Adaui V, Valencia BM, Martinez D, Alba M, Castrillon C, Cruz M, Cruz I, Van der Auwera G, Llanos-Cuentas A, Dujardin JC, Arevalo J. Real-time PCR assay for detection and quantification of Leishmania (Viannia) organisms in skin and mucosal lesions: exploratory study of parasite load and clinical parameters. J Clin Microbiol. 2013 Jun;51(6):1826-33.

Valencia BM, Miller D, Witzig RS, Boggild AK, Llanos-Cuentas A. Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. PLoS Negl Trop Dis. 2013 May 2;7(5):e2196.

Veland N, Valencia BM, Alba M, Adaui V, Llanos-Cuentas A, Arevalo J, Boggild AK. Simultaneous infection with Leishmania (Viannia) braziliensis and L. (V.) lainsoni in a Peruvian patient with cutaneous leishmaniasis. Am J Trop Med Hyg. 2013 Apr;88(4):774-

Zvietcovich F, Castañeda B, Valencia B, Llanos-Cuentas A. A 3D assessment tool for accurate volume measurement for monitoring the evolution of cutaneous leishmaniasis wounds. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2025-8.

Valencia BM, Veland N, Alba M, Adaui V, Arevalo J, Low DE, Llanos-Cuentas A, Boggild AK. Non-invasive cytology brush PCR for the diagnosis and causative species identification of American cutaneous leishmaniasis in Peru. PLoS One. 2012;7(11):e49738.

Boggild AK, Valencia BM, Espinosa D, Veland N, Ramos AP, Arevalo J, Llanos-Cuentas A, Low DE. Detection and species identification of Leishmania DNA from filter paper lesion impressions for patients with American cutaneous leishmaniasis. Clin Infect Dis. 2010 Jan 1;50(1):e1-6.

Relevant conference presentations (full list available in https://publons.com/researcher/3011676/braulio-markvalencia-arroyo/)

Valencia BM. Symposium 51 - Severe Tropical Diseases in the ICU: Yellow fever. 69th Annual Meeting of the American Society of Tropical Medicine and Hygiene. November 15-19, 2020. Oral presentation (virtual meeting due to COVID-19).

Valencia BM, Li H, Cvejic E, Rodrigo C, Lloyd A. Host determinants of the acute sickness response and the severity and outcome of acute infections: A Genetic analysis in the Dubbo Infection Outcomes Study (DIOS). 30th European Congress of Clinical Microbiology and Infectious Diseases. April 18-21, 2020. Poster presentation (virtual meeting due to COVID-19).

Valencia BM, Lau R, Kariyawasam R, Shao E, Llanos-Cuentas A, Boggild AK. Point-of-Care Molecular Diagnosis of Cutaneous Leishmaniasis and Intercurrent Fungal and Mycobacterial Infections. 14th International Congress on Infectious Diseases. March 1-4, 2018, Buenos Aires Argentina. Poster presentation.

Valencia BM, Garcia L, Rojas E, Alba M, Montaño N, et al. Field sampling at endemic villages and molecular diagnosis at distant research centers: a coupled and articulated strategy for molecular diagnosis and strain identification of causative agents in suspected cutaneous leishmaniasis lesions in rural cities from Peru and Bolivia. 6th World Congress on Leishmaniasis. May 16-20, 2017, Toledo Spain. Oral presentation.

Valencia BM, Jara M, Adaui V, Chantry M, Ramos AP, Arevalo J, et al. Leishmania RNA virus-1 is equally distributed among severe and non-severe phenotypes in a prospective cohort of American Tegumentary Leishmaniasis. 6th World Congress on Leishmaniasis. May 16-20, 2017, Toledo Spain. Oral presentation.

Valencia BM, Lau R, Kariyawasam R, Llanos-Cuentas A, Boggild AK. Validation of point-of-care molecular testing for diagnosis of ulcers due to Leishmania, Fungi and Mycobacteria. 65th Annual Meeting of the American Society of Tropical Medicine and Hygiene. November 13-17, 2016, Atlanta USA. Poster presentation.

Valencia BM, Zviertcovich F, Lavarello R, Boggild AK, Castañeda B, Llanos-Cuentas A. Electronic volumetric assessment during sodium stibogluconate therapy in patients with cutaneous leishmaniasis: a promising technique using digital 3D models. 64th Annual Meeting of the American Society of Tropical Medicine and Hygiene. October 25-29, 2015, Philadelphia USA. Oral presentation

Book chapters and WHO technical reports

Bajis S, Bull R, Causer L, Kaldor J, Legrand N, Martinello M, McGregor S, Naruka E, Ronnachitand A, Valencia BM, Low N. Human T-lymphotropic virus type 1: technical report. Geneva: World Health Organization; 2021. eISBN 978- 92-4-002022-1.

Llanos-Cuentas A, Carvalho EM, Lima-Machado PR, Valencia BM, Ramos AP, Soto J. Chapter 4: Mucosal Leishmaniasis. In: Interactive Atlas of Leishmaniasis in the Americas: clinical aspects and differential diagnoses. Washington, D.C.: Panamerican Health Organization; 2020. eISBN: 978-92-75-32191-1.

Llanos-Cuentas A, Valencia BM, Petersen CA. Neurological manifestations of human leishmaniasis. Handb Clin Neurol. 2013;114:193-8.

Research Activity Links:

Researchgate

Publons

Teaching & Supervision

I am available to supervise:

Yes

Social Media

LinkedIn:

https://www.linkedin.com/in/braulio-mark-valencia-arroyo-b036ba42/

Dr Braulio M. Valencia Arroyo

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