Dr. Braulio M. Valencia Arroyo

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PhD Student

Viral Immunology Systems Program

barroyo@kirby.unsw.edu.au

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Bio:

Dr. Valencia was born in Cusco, Peru and did medical school at Universidad Peruana Cayetano Heredia (UPCH). Subsequently, he did his postgraduates studies (Research and Clinical training) at The Institute of Tropical Medicine Alexander von Humboldt (IMTAvH), UPCH. During and upon finishing the postgraduate training, he has performed as a clinical researcher at IMTAvH as well as professor of undergraduate and postgraduate courses at UPCH, the University of Alabama at Birmingham, University of California, Irvine, Broward College, and University of Texas Health Science Center at Houston. Dr. Valencia has developed collaborative research with different institutions: the University of Toronto, Drugs for Neglected Diseases initiative (DNDi), Institute of Tropical Medicine Antwerp, Infectious Diseases Research Institute (IDRI), Walter Reed Army Institute of Research, Tulane University, Duke University, and The University of Alabama at Birmingham.

His research interest focused on the point of care diagnostics, clinical trials, vaccine clinical trials and Health Systems Implementation in Neglected Tropical Diseases. In addition to the former, his current research interest is the understanding of immunogenetic determinants of susceptibility and resistance to infectious diseases, particularly Hepatitis C, Epstein-Barr virus, Ross River virus, Coxiella burnetii, and Influenza.

Qualifications:

Diploma in Tropical and Infectious Diseases - Universidad Peruana Cayetano Heredia, Lima, Peru, 2011-2016

Master of Science, Control of Tropical and Infectious Diseases - Universidad Peruana Cayetano Heredia, Lima, Peru, 2009-2011

Medical Doctor (MBBS) - Universidad Peruana Cayetano Heredia, Lima, Peru, 2001-2008

Grants:

Point of Care testing for the confirmatory diagnosis of Tegumentary Leishmaniasis: Usefulness of two molecular approaches in endemic villages from Peru. The University of Alabama at Birmingham – Universidad Peruana Cayetano Heredia. UAB-IMTAvH Collaborative Research Grant from the Gorgas Course (2016-2018).

Ultrasonographic techniques for early identification of treatment failure in cutaneous leishmaniasis. Fund for Innovation, Science, and Technology – Peruvian Government (2016-2018).

Parasite density as a biomarker of therapeutic response in cutaneous leishmaniasis: a multidisciplinary study based on volumetric and parasite load estimations. Fogarty Global Health Fellows – National Institute of Health (2015-2016).

Epidemiology of Mycobacterium ulcerans in the Ecuadorian-Peruvian frontier. FA3 Strategic Network on Neglected Tropical Diseases and Zoonoses (SNNDZ, Belgium cooperation, 2014-2015).

Evaluation of non-invasive sampling based on cytology brushes for PCR-based diagnosis and typing of Leishmania in cutaneous leishmaniasis-endemic regions of Latin America. FA3 Strategic Network on Neglected Tropical Diseases and Zoonoses (SNNDZ, Belgium cooperation, 2013-2014).

Leishmania RNA virus as a possible determinant of pathogenicity in American Tegumentary Leishmaniasis: detection and quantification of viral load clinic samples. International Society for Infectious diseases small grant (ISID small grant, 2012-2013).

Research

Research activities:

Publications (Peer-review journals)

Barros N, Vasquez N, Woll F, Sanchez C, Valencia B, Llanos-Cuentas A, White AC Jr, Montes M. Regulatory T-Cell Dynamics in Cutaneous and Mucocutaneous Leishmaniasis due to Leishmania braziliensis. Am J Trop Med Hyg. 2018 Mar;98(3):753-758.

Kariyawasam R, Grewal J, Lau R, Purssell A, Valencia BM, Llanos-Cuentas A, Boggild AK. Influence of Leishmania RNA Virus 1 on Proinflammatory Biomarker Expression in a Human Macrophage Model of American Tegumentary Leishmaniasis. J Infect Dis. 2017 Oct 17;216(7):877-886.

Valencia BM, Jara M, Adaui V, Alba M, Lau R, Arevalo J, Llanos-Cuentas A, Boggild AK. Quantitative Kinetoplast DNA Assessment During Treatment of Mucosal Leishmaniasis as a Potential Biomarker of Outcome: A Pilot Study. Am J Trop Med Hyg. 2016 Jan;94(1):107-13.

Suárez M, Valencia BM, Jara M, Alba M, Boggild AK, Dujardin JC, Llanos-Cuentas A, Arevalo J, Adaui V. Quantification of Leishmania (Viannia) Kinetoplast DNA in Ulcers of Cutaneous Leishmaniasis Reveals Inter-site and Inter-sampling Variability in Parasite Load. PLoS Negl Trop Dis. 2015 Jul 23;9(7):e0003936.

Jara M, Adaui V, Valencia BM, Martinez D, Alba M, Castrillon C, Cruz M, Cruz I, Van der Auwera G, Llanos-Cuentas A, Dujardin JC, Arevalo J. Real-time PCR assay for detection and quantification of Leishmania (Viannia) organisms in skin and mucosal lesions: exploratory study of parasite load and clinical parameters. J Clin Microbiol. 2013 Jun;51(6):1826-33.

Valencia BM, Miller D, Witzig RS, Boggild AK, Llanos-Cuentas A. Novel low-cost thermotherapy for cutaneous leishmaniasis in Peru. PLoS Negl Trop Dis. 2013 May 2;7(5):e2196.

Veland N, Valencia BM, Alba M, Adaui V, Llanos-Cuentas A, Arevalo J, Boggild AK. Simultaneous infection with Leishmania (Viannia) braziliensis and L. (V.) lainsoni in a Peruvian patient with cutaneous leishmaniasis. Am J Trop Med Hyg. 2013 Apr;88(4):774-

Fraga J, Veland N, Montalvo AM, Praet N, Boggild AK, Valencia BM, Arévalo J, Llanos-Cuentas A, Dujardin JC, Van der Auwera G. Accurate and rapid species typing from cutaneous and mucocutaneous leishmaniasis lesions of the New World. Diagn Microbiol Infect Dis. 2012 Oct;74(2):142-50.

Veland N, Boggild AK, Valencia C, Valencia BM, Llanos-Cuentas A, Van der Auwera G, Dujardin JC, Arevalo J. Leishmania (Viannia) species identification on clinical samples from cutaneous leishmaniasis patients in Peru: assessment of a molecular stepwise approach. J Clin Microbiol. 2012 Feb;50(2):495-8.

Zvietcovich F, Castañeda B, Valencia B, Llanos-Cuentas A. A 3D assessment tool for accurate volume measurement for monitoring the evolution of cutaneous leishmaniasis wounds. Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2025-8.

Valencia BM, Veland N, Alba M, Adaui V, Arevalo J, Low DE, Llanos-Cuentas A, Boggild AK. Non-invasive cytology brush PCR for the diagnosis and causative species identification of American cutaneous leishmaniasis in Peru. PLoS One. 2012;7(11):e49738.

Veland N, Espinosa D, Valencia BM, Ramos AP, Calderon F, Arevalo J, Low DE, Llanos-Cuentas A, Boggild AK. Polymerase chain reaction detection of Leishmania kDNA from the urine of Peruvian patients with cutaneous and mucocutaneous leishmaniasis. Am J Trop Med Hyg. 2011 Apr;84(4):556-61.

Boggild AK, Valencia BM, Espinosa D, Veland N, Ramos AP, Arevalo J, Llanos-Cuentas A, Low DE. Detection and species identification of Leishmania DNA from filter paper lesion impressions for patients with American cutaneous leishmaniasis. Clin Infect Dis. 2010 Jan 1;50(1):e1-6.

Book chapters

Llanos-Cuentas A, Valencia BM, Petersen CA. Neurological manifestations of human leishmaniasis. Handb Clin Neurol. 2013;114:193-8.

Manuscript reviewer

Parasites and vectors (https://parasitesandvectors.biomedcentral.com/about?gclid=EAIaIQobChMIwM...)

Experimental Parasitology (https://www.journals.elsevier.com/experimental-parasitology)

Reviews in Medical Microbiology (https://journals.lww.com/revmedmicrobiol/Pages/default.aspx)

Microbial Pathogenesis (https://www.journals.elsevier.com/microbial-pathogenesis)

PLOS ONE (http://journals.plos.org/plosone/)

Tropical Diseases, Travel Medicine and Vaccines (https://tdtmvjournal.biomedcentral.com/)

Journal of Clinical Rheumatology (https://journals.lww.com/jclinrheum/pages/default.aspx)

The American Journal of Tropical Medicine and Hygiene (https://www.ajtmh.org/)

Research Activity Links: