Dr. Lok completed his Bachelor of Medicine and Bachelor of Surgery (MBBS) in 2010 and Doctor of Medicine (MD) in Microbiology & Infectious Diseases in 2015. After completing MD, he worked as an Assistant Professor at B.P. Koirala Institute of Health Sciences, Dharan, Nepal. He was primarily involved in teaching microbiology to medical and dental students, supervising diagnostic microbiology laboratory, and research activities. Initially, his research was focused on bacterial infections and antimicrobial resistance. He has worked as a microbiologist in an expert team during Dengue outbreak in 2019 and COVID-19 surveillance in 2020. His research interests are antimicrobial resistance, virology, and immunology. His current research focuses on broadly neutralizing antibodies against the emerging variants of SARS-COV-2 and autoantibodies in patients with COVID-19.
PhD Student
Dr Lok Bahadur Shrestha
MBBS, MD (Microbiology & Infectious Diseases)
Publications
Journal articles
Walker SJ; Dawson O; Sheehan Y; Shrestha LB; Lloyd AR; Sheehan J; Maduka N; Cabezas J; Kronfli N; Akiyama MJ, 2024, 'Co-designing the INHSU Prisons Hepatitis C Advocacy Toolkit using the Advocacy Strategy Framework', International Journal of Drug Policy, 134, http://dx.doi.org/10.1016/j.drugpo.2024.104628
2024
Walker SJ; Shrestha LB; Lloyd AR; Dawson O; Sheehan Y; Sheehan J; Maduka NBC; Cabezas J; Akiyama MJ; Kronfli N, 2024, 'Barriers and advocacy needs for hepatitis C services in prisons: Informing the prisons hepatitis C advocacy toolkit', International Journal of Drug Policy, 126, http://dx.doi.org/10.1016/j.drugpo.2024.104386
2024
Mainali N; Shrestha AB; Shrestha S; Chapagain S; Khanal B; Shrestha LB; Shrestha S; Jaiswal V, 2024, 'mRNA vaccines as a revolutionary approach to combat cancer', Postgraduate Medical Journal, 100, pp. 279 - 282, http://dx.doi.org/10.1093/postmj/qgad138
2024
Basnet A; Tamang B; Shrestha MR; Shrestha LB; Rai JR; Maharjan R; Dahal S; Shrestha P; Rai SK, 2023, 'Assessment of four in vitro phenotypic biofilm detection methods in relation to antimicrobial resistance in aerobic clinical bacterial isolates', PLoS ONE, 18, http://dx.doi.org/10.1371/journal.pone.0294646
2023
Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”', Journal of Virology, 97, http://dx.doi.org/10.1128/jvi.00451-23
2023
Speck P; Mackenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peters J; Kriiger-Loterio R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”', mBio, 14, http://dx.doi.org/10.1128/mbio.00815-23
2023
Foster CSP; Bull RA; Tedla N; Santiago F; Agapiou D; Adhikari A; Walker GJ; Shrestha LB; Van Hal SJ; Kim KW; Rawlinson WD, 2023, 'Persistence of a Frameshifting Deletion in SARS-CoV-2 ORF7a for the Duration of a Major Outbreak', Viruses, 15, http://dx.doi.org/10.3390/v15020522
2023
Speck P; MacKenzie J; Bull RA; Slobedman B; Drummer H; Fraser J; Herrero L; Helbig K; Londrigan S; Moseley G; Prow N; Hansman G; Edwards R; Ahlenstiel C; Abendroth A; Tscharke D; Hobson-Peter J; Kriiger-Loteri R; Parry R; Marsh G; Harding E; Jacques DA; Gartner MJ; Lee WS; McAuley J; Vaz P; Sainsbury F; Tate MD; Sinclair J; Imrie A; Rawlinson S; Harman A; Carr JM; Monson EA; Hibma M; Mahony TJ; Tu T; Center RJ; Shrestha LB; Hall R; Warner M; Ward V; Anderson DE; Eyre NS; Netzler NE; Peel AJ; Revill P; Beard M; Legione AR; Spencer AJ; Idris A; Forwood J; Sarker S; Purcell DFJ; Bartlett N; Deerain JM; Brew BJ; Asgari S; Farrell H; Khromykh A; Tuipulotu DE; Anderson D; Mese S; Tayyar Y; Edenborough K; Uddin JM; Hussain A; Daymond CJI; Agius J; Johnson KN; Shirmast P; Abedinzadeshahri M; MacDiarmid R; Ashley CL; Laws J; Furfaro LL; Burton TD; Johnson SMR; Telikani Z; Petrone M; Roby JA; Samer C; Suhrbier A; Van Der Kamp A; Cunningham A; Donato C; Mahar J; Black WD; Vasudevan S; Lenchine R; Spann K; Rawle DJ; Rudd P; Neil J; Kingston R; Newsome TP; Kim KW; Mak J; Lowry K; Bryant N, 2023, 'Statement in Support of: "Virology under the Microscope - a Call for Rational Discourse"', mSphere, 8, http://dx.doi.org/10.1128/msphere.00165-23
2023
Basnet A; Chand AB; Pokhrel N; Acharya S; Gurung P; Khanal LK; Shrestha K; Shrestha LB; Raghubanshi BR, 2023, 'Antimicrobial Susceptibility Pattern in Opportunistic Pathogens Isolated from Immunocompromised Patients', Journal of Nepal Health Research Council, 20, pp. 664 - 671, http://dx.doi.org/10.33314/jnhrc.v20i3.4047
2023
Basnet A; Chand AB; Pokhrel N; Gurung P; Rai JR; Bajracharya S; Acharya S; Shrestha LB, 2022, 'Status of Intestinal Parasitic Infections in a Tertiary Care Center', Journal of Nepal Health Research Council, 20, pp. 505 - 509, http://dx.doi.org/10.33314/jnhrc.v20i02.4049
2022
Shrestha LB; Foster C; Rawlinson W; Tedla N; Bull RA, 2022, 'Evolution of the SARS-CoV-2 omicron variants BA.1 to BA.5: Implications for immune escape and transmission', Reviews in Medical Virology, 32, http://dx.doi.org/10.1002/rmv.2381
2022
Pokharel K; Dawadi BR; Aryal B; Shrestha LB, 2022, 'PROFILE OF BREAKTHROUGH INFECTION OF COVID-19 IN A TERTIARY CARE HOSPITAL: A DESCRIPTIVE CROSS-SECTIONAL STUDY', Journal of Chitwan Medical College, 12, pp. 62 - 64, http://dx.doi.org/10.54530/jcmc.591
2022
Chand AB; Basnet A; Shrestha LB; Sen B; Priyadarshinee A; Amatya I; Rajbanshi BR, 2022, 'Significance of Hematological Biomarkers in Association to Syphilitic Patients', Journal of Nepal Health Research Council, 20, pp. 426 - 430, http://dx.doi.org/10.33314/jnhrc.v20i02.4074
2022
Chand AB; Singh S; Bhatt LR; Sen B; Joshi YP; Joshi P; Shrestha LB; Shrestha SKD; Basnet A, 2022, 'Vitamin D Deficiency among Patients Visiting Outpatient Departments in a Tertiary Care Centre: A Descriptive Cross-sectional Study', Journal of the Nepal Medical Association, 60, pp. 356 - 359, http://dx.doi.org/10.31729/jnma.7299
2022
Shrestha LB; Yadav GK; Pradhan S; Sharma A; Pandit T; Chhetry R; Khanal B, 2022, 'Co-infection of Hepatitis B and Hepatitis C among HIV-infected patients: A cross-sectional study from tertiary care hospital of eastern Nepal', PLOS ONE, 17, http://dx.doi.org/10.1371/journal.pone.0264791
2022
Pokharel K; Dawadi BR; Shrestha LB, 2022, 'Role of Biofilm in Bacterial Infection and Antimicrobial Resistanc', Journal of the Nepal Medical Association, 60, pp. 836 - 840, http://dx.doi.org/10.31729/jnma.7580
2022
Basnet A; Chand AB; Shrestha LB; Pokhrel N; Karki L; Shrestha SKD; Tamang B; Shrestha MR; Dulal M; Rai JR, 2022, 'Co-infection of Uropathogenic Escherichia coli among COVID-19 Patients Admitted to a Tertiary Care Centre: A Descriptive Cross-sectional Study', Journal of the Nepal Medical Association, 60, pp. 294 - 298, http://dx.doi.org/10.31729/jnma.7376
2022
Shrestha DB; Budhathoki P; Gurung B; Subedi S; Aryal S; Basukala A; Aryal B; Adhikari A; Poudel A; Yadav GK; Khoury M; Rayamajhee B; Shrestha LB, 2022, 'Epidemiology of dengue in SAARC territory: a systematic review and meta-analysis', Parasites and Vectors, 15, http://dx.doi.org/10.1186/s13071-022-05409-1
2022
Balachandran H; Phetsouphanh C; Agapiou D; Adhikari A; Rodrigo C; Hammoud M; Shrestha LB; Keoshkerian E; Gupta M; Turville S; Christ D; King C; Sasson SC; Bartlett A; Grubor-Bauk B; Rawlinson W; Aggarwal A; Stella AO; Klemm V; Mina MM; Post JJ; Hudson B; Gilroy N; Konecny P; Ahlenstiel G; Dwyer DE; Sorrell TC; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA, 2022, 'Maintenance of broad neutralizing antibodies and memory B cells 1 year post-infection is predicted by SARS-CoV-2-specific CD4+ T cell responses', Cell Reports, 38, pp. 110345, http://dx.doi.org/10.1016/j.celrep.2022.110345
2022
Shrestha M; Baral R; Shrestha LB, 2021, 'Metallo-β lactamase producing non-fermentative gram-negative bacilli from various clinical isolates in a tertiary care hospital: A descriptive cross-sectional study', Journal of the Nepal Medical Association, 59, pp. 875 - 880, http://dx.doi.org/10.31729/jnma.6408
2021
Syangtan G; Bista S; Dawadi P; Rayamajhee B; Shrestha LB; Tuladhar R; Joshi DR, 2021, 'Asymptomatic SARS-CoV-2 Carriers: A Systematic Review and Meta-Analysis', Frontiers in Public Health, 8, http://dx.doi.org/10.3389/fpubh.2020.587374
2021
Shrestha LB; Tedla N; Bull RA, 2021, 'Broadly-Neutralizing Antibodies Against Emerging SARS-CoV-2 Variants', Frontiers in Immunology, 12, http://dx.doi.org/10.3389/fimmu.2021.752003
2021
Shrestha DB; Budhathoki P; Sedhai YR; Shrestha LB; Awal S; Upadhaya Regmi B; Yadav J; Baniya R; Thapaliya S; Dangal G, 2021, 'Prevalence of Hepatitis B and C among HIV Infected Patients in Nepal over 1990-2020.', Kathmandu Univ Med J (KUMJ), 19, pp. 132 - 139, https://www.ncbi.nlm.nih.gov/pubmed/34812172
2021
Shrestha LB; Syangtan G; Basnet A; Acharya KP; Chand AB; Pokhrel K, 2021, 'Methicillin-resistant staphylococcus aureus in nepal', Journal of the Nepal Medical Association, 59, pp. 518 - 522, http://dx.doi.org/10.31729/JNMA.6251
2021
Baral R; Shrestha LB; Ortuno-Gutierrez N; Pyakure P; Rai B; Rimal SP; Singh S; Sharma SK; Khanal B; Selvaraj K; Kumar AM, 2021, 'Low yield but high levels of multidrug resistance in urinary tract infections in a tertiary hospital, Nepal', PUBLIC HEALTH ACTION, 11, pp. 70 - 76, http://dx.doi.org/10.5588/pha.21.0044
2021
Shrestha LB; Bhattarai NR; Rai K; Khanal B, 2020, 'Antibiotic resistance and mecA gene characterization of coauglase-negative Staphylococci isolated form clinical samples in Nepal.', Infection and drug resistance, 13, pp. 3163 - 69
2020
Shrestha LB; Pokharel K, 2020, 'Standard operating procedure for specimen collection, packaging and transport for diagnosis of SARS-CoV-2', Journal of the Nepal Medical Association, 58, http://dx.doi.org/10.31729/jnma.5260
2020
Shrestha LB, 2020, 'Multi-drug resistant and extended-spectrum lactamase producing bacteria in pediatric urinary tract infection', INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 101, pp. 27 - 27, http://dx.doi.org/10.1016/j.ijid.2020.09.106
2020
Shrestha LB; Baral R; Khanal B, 2019, 'Comparative study of antimicrobial resistance and biofilm formation among Gram-positive uropathogens isolated from community-acquired urinary tract infections and catheter-associated urinary tract infections.', Infection and drug resistance, 12, pp. 957 - 963, http://dx.doi.org/10.2147/IDR.S200988
2019
Dumaru R; Baral R; Shrestha LBLB, 2019, 'Study of biofilm formation and antibiotic resistance pattern of gram-negative Bacilli among the clinical isolates at BPKIHS, Dharan', BMC Research Notes, 12, http://dx.doi.org/10.1186/s13104-019-4084-8
2019
Shrestha LB; Bhattarai NR; Khanal B, 2019, 'Bacteriological Profile and Antimicrobial Susceptibility Pattern among Isolates Obtained From Body Fluids.', Journal of Nepal Health Research Council, 17, pp. 173 - 177, http://dx.doi.org/10.33314/jnhrc.v0i0.1656
2019
Shah C; Baral R; Bartaula B; Shrestha LB, 2019, 'Virulence factors of uropathogenic Escherichia coli (UPEC) and correlation with antimicrobial resistance.', BMC microbiology, 19, pp. 204 - 204, http://dx.doi.org/10.1186/s12866-019-1587-3
2019
Shrestha LB; Baral R; Poudel P; Khanal B, 2019, 'Clinical, etiological and antimicrobial susceptibility profile of pediatric urinary tract infections in a tertiary care hospital of Nepal.', BMC pediatrics, 19, pp. 36 - 36, http://dx.doi.org/10.1186/s12887-019-1410-1
2019
Shrestha L; Bhattarai NR; Khanal B, 2018, 'Comparative evaluation of methods for the detection of biofilm formation in coagulase-negative staphylococci and correlation with antibiogram', Infection and Drug Resistance, Volume 11, pp. 607 - 613, http://dx.doi.org/10.2147/IDR.S159764
2018
Shrestha LB; Bhattarai NR; Khanal B, 2017, 'Antibiotic resistance and biofilm formation among coagulase-negative staphylococci isolated from clinical samples at a tertiary care hospital of eastern Nepal', Antimicrobial Resistance and Infection Control, 6, pp. 1 - 7, http://dx.doi.org/10.1186/s13756-017-0251-7
2017
Preprints
Foster CSP; Bull R; Tedla N; Santiago F; Agapiou D; Adhikari A; Walker G; Shrestha LB; van Hal S; Kim KW; Rawlinson W, 2022, Persistence of a SARS-CoV-2 variant with a frameshifting deletion for the duration of a major outbreak, http://dx.doi.org/10.1101/2022.09.06.22279658
2022
Syangtan G; Bista S; Dawadi P; Rayamajhee B; Shrestha LB; Tuladhar R; Joshi DR, 2020, Asymptomatic people with SARS-CoV-2 as unseen carriers of COVID-19: A systematic review and meta-analysis, http://dx.doi.org/10.21203/rs.3.rs-39512/v1
2020
Balachandran H; Phetsouphanh C; Agapiou D; Adhikari A; Rodrigo C; Hammoud M; Shrestha LB; Keoshkerian E; Gupta M; Turville S; Christ D; King C; Sasson S; Bartlett A; Grubor-Bauk B; Rawlinson W; Aggarwal A; Stella AO; Klemm V; Mina MM; Post JJ; Hudson B; Gilroy N; Konecny P; Ahlenstiel G; Dwyer D; Sorrell TC; Kelleher A; Tedla N; Lloyd AR; Martinello M; Bull RA, Maintenance of Broad Neutralising Antibodies and Memory B Cells 12 Months Post-Infection Is Predicted by SARS-CoV-2 Specific CD4+ T Cell Responses, http://dx.doi.org/10.2139/ssrn.3920641
Conference Papers
Khanal B; Yadav A; Pandit T; Shrestha LB; Raj BN, 2016, 'Multidrug resistant blood culture isolates: An experience from a tertiary care hospital in Eastern Nepal', in INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, ELSEVIER SCI LTD, pp. 97 - 97, http://dx.doi.org/10.1016/j.ijid.2016.02.256
2016
Awards
Scientia Ph.D. Scholarship by University of New South Wales, Sydney, Australia (2020) Bill & Melinda Gates Young Scientist Award for research selected at 19th International Congress On Infectious Diseases (2020) Travel Grant for HIC-Vac Network Annual Meeting in Windsor, UK (2019) Travel Grant for ESCMID funded Observership Programme in CHUV Hospital, Switzerland (2019) Travel Grant for VALIDATE Network 3rd Annual Meeting and VALIDATE-British Society for Immunology Conference in Wembley, UK (2019) Young Scientist Grant for "Updates on Tuberculosis and other Mycobacterial Infection" in National University Hospital, Singapore (2019) Travel Grant for ESCMID funded Observership Programme in Erciyes University, Turkey (2018) Grant for "ASID/ESCMID Course on Infectious Diseases in Pregnant Women, Fetuses and Newborns" in Sydney, Australia (2018) Travel Grant for IMPRINT 1st Annual Network Meeting in Kingston Upon Thames, UK (2018) Travel Grant for GCRF Networks Vaccinology Course in Bangkok, Thailand (2018) International Resource Faculty for "International Course on Immune Response in Health and Disease" in Kerala, India (2017) Gold Medalist: MD Microbiology & Infectious Diseases at B.P. Koirala Institute of Health Sciences, Dharan, Nepal (Batch 2012-15)