Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is the main cause of death in HIV-1-infected people. Our study explores the impact of the Mtb-induced inflammatory microenvironment on HIV-1 persistence. We found impaired HIV-1-specific CD8 T-cell response, leading to higher infected cell proportions at the coinfection site.
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Dr Gabriel Duette In 2019, Dr Duette obtained his PhD from the University of Buenos Aires, focusing on HIV immunopathology and Extracellular Vesicles. Since September 2019, as a Postdoctoral researcher at The Westmead Institute for Medical Research, he has studied HIV persistence in effector memory T cells and the impact of type 1 IFN on HIV reactivation. Additionally, he contributed to COVID research. Currently, Dr Duette investigates HIV/TB coinfection's effect on the HIV reservoir and works on generating CD8 CAR T cells for HIV eradication. Moreover, he aims to understand transient HIV control during an analytical treatment interruption (ATI). |
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