Dr Sarah Sasson – Local villains: Tissue Resident Memory T cells in Checkpoint Inhibitor Colitis

Event type: 
Seminar
Event date: 
Tuesday, 16 November 2021 - 1:00pm to 2:00pm
Cost: 
Free
Location: 

Webinar via Zoom
Please click on the link just before the start of the webinar

Contact for inquiries: 
Rata Joseph, +61 (2) 9385 0900 or info@kirby.unsw.edu.au
Booking deadline: 

 

Kirby Institute Seminar Series presents

Dr Sarah Sasson  

Dr Sarah Sasson
Scientia Senior Lecturer, Immunovirology and Pathogenesis Program, Kirby Institute

Sarah Sasson is a Scientia Senior Lecturer at the Kirby Institute and a Clinical Immunologist and Immunopathologist at Westmead Hospital and NSW Health Pathology. In 2018–2019, she undertook postdoctoral training at the University of Oxford as part of the Oxford-BMS Fellowship Program.

 

Abstract

Immune Checkpoint Inhibitors (ICI) are revolutionising the treatment of many cancers, but come at the cost of immune-related adverse events (irAE). Checkpoint-inhibitor associated colitis is among the most prevalent toxicity and has the highest mortality. Investigations into the cellular and molecular pathogenesis of this novel inflammatory bowel disease using high-dimensional flow cytometry, spectral immunofluoresence microscopy, bulk/plex and single cell RNASeq will be presented. These findings revealed a pathogenic role for CD8+ Tissue Resident Memory (TRM) cells and provide a rationale for novel therapeutic strategies.

 

Opinions expressed in the Kirby Institute Seminar Series are solely those of the speaker and do not necessarily represent the views or opinions of the Kirby Institute or UNSW.

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