Mr Harikrishnan Balachandran

PUBLICATIONS: Balachandran H, Phetsouphanh C, Agapiou D, Adhikari A, Rodrigo C, Hammoud M, Shrestha LB, Keoshkerian E, Gupta M, Turville S, Christ D, King C, Sasson S, Bartlett A,  Grubor-Bauk B, Rawlinson W, Aggarwal A, Stella AO, Klemm V, Mina MM. Post JJ, Hudson B, Gilroy N, Konecny P,  Ahlenstiel G, Dwyer D,  Sorrell T, Kelleher A,  Tedla N,   Lloyd AR, Martinello M, Bull RA. Maintenance of Broad Neutralising Antibodies and Memory B Cells 12 Months Post-Infection Is Predicted by SARS-CoV-2 Specific CD4+ T Cell Responses. Sneak Peek at Cell Reports. Available at SSRN: https://ssrn.com/abstract=3920641 or http://dx.doi.org/10.2139/ssrn.39...   Abayasingam A*, Balachandran H*, Agapiou D, Hammoud M, Rodrigo C, Keoshkerian E, Li H, Brasher NA, Christ D, Rouet R, Burnet D, Grubor-Bauk B, Rawlinson W, Turville S, Aggarwal A, Stella AO, Fichter C, Brilot F, Mina M, Post JJ, Hudson B, Gilroy N, Dwyer D, Sasson SC, Tea F, Pilli D, Kelleher A, Tedla N, Lloyd AR, Martinello M, Bull RA; COSIN Study Group. Long-term persistence of RBD+ memory B cells encoding neutralizing antibodies in SARS-CoV-2 infection. Cell Rep Med. 2021 Apr 20;2(4):100228. doi: 10.1016/j.xcrm.2021.100228. Epub 2021 Mar 14.   Burnett, D.L., Jackson, K.J.L., Langley, D.B., Aggrawal, A., Stella, A.O., Johansen, M.D., Balachandran, H., Lenthall, H., Rouet, R., Walker, G., Saunders, B.M., Singh, M., Li, H., Henry, J.Y., Jackson, J., Stewart, A.G., Witthauer, F., Spence, M.A., Hansbro, N.G., Jackson, C., Schofield, P., Milthorpe, C., Martinello, M., Schulz, S.R., Roth, E., Kelleher, A., Emery, S., Britton, W.J., Rawlinson, W.D., Karl, R., Schäfer, S., Winkler, T.H., Brink, R., Bull, R.A., Hansbro, P.M., Jäck, H.- M., Turville, S., Christ, D., Goodnow, C.C., Immunizations with diverse sarbecovirus receptor binding domains elicit SARS-CoV-2 neutralizing antibodies against a conserved site of vulnerability, Immunity (2021), doi: https://doi.org/10.1016/j.immuni.2021.10.019.   Garcia Valtanen P, Hope CM, Masavuli MG, Yeow AL, Balachandran H, Mekonnen ZA, Al-Delfi Z, Abayasingam A, Agapiou D, Gummow J, Ferguson C, O’Connor S, McCartney EM, Lynn DJ, Maddern G, Gowans EJ, Reddi BAJ, Shaw D, Chuan KL, Beard M, Weiskopf D, Sette A, Bull RA, Barry SC, Grubor-Bauk B, 'One Year Later' - SARS-CoV-2-Specific Immunity in Mild Cases of COVID-19. Preprints with The Lancet. Available at SSRN:  https://ssrn.com/abstract=3859298 or http://dx.doi.org/10.2139/ssrn.38...   Bradley T, Pollara J, Santra S, Vandergrift N, Pittala S, Bailey-Kellogg C, Shen X, Parks R, Goodman D, Eaton A, Balachandran H, Mach LV, Saunders KO, Weiner JA, Scearce R, Sutherland LL, Phogat S, Tartaglia J, Reed SG, Hu SL, Theis JF, Pinter A, Montefiori DC, Kepler TB, Peachman KK, Rao M, Michael NL, Suscovich TJ, Alter G, Ackerman ME, Moody MA, Liao HX, Tomaras G, Ferrari G, Korber BT, Haynes BF. Pentavalent HIV-1 vaccine protects against simian-human immunodeficiency virus challenge. Nat Commun. 2017 Jun 8;8:15711. doi: 10.1038/ncomms15711.   Pardi N, Hogan MJ, Pelc RS, Muramatsu H, Andersen H, DeMaso CR, Dowd KA, Sutherland LL, Scearce RM, Parks R, Wagner W, Granados A, Greenhouse J, Walker M, Willis E, Yu JS, McGee CE, Sempowski GD, Mui BL, Tam YK, Huang YJ, Vanlandingham D, Holmes VM, Balachandran H, Sahu S, Lifton M, Higgs S, Hensley SE, Madden TD, Hope MJ, Karikó K, Santra S, Graham BS, Lewis MG, Pierson TC, Haynes BF, Weissman D. Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination. Nature. 2017 Mar 9;543(7644):248-251. doi: 10.1038/nature21428. Epub 2017 Feb 2.   Asmal M, Lane S, Tian M, Nickel G, Venner C, Dirk B, Dikeakos J, Luedemann C, Mach L, Balachandran H, Buzby A, Rao S, Letvin N, Gao Y, Arts EJ. Pathogenic infection of Rhesus macaques by an evolving SIV-HIV derived from CCR5-using envelope genes of acute HIV-1 infections. Virology. 2016 Dec;499:298-312. doi: 10.1016/j.virol.2016.09.021.   Negri D, Blasi M, LaBranche C, Parks R, Balachandran H, Lifton M, Shen X, Denny T, Ferrari G, Vescio MF, Andersen H, Montefiori DC, Tomaras GD, Liao HX, Santra S, Haynes BF, Klotman ME, Cara A. Immunization with an SIV-based IDLV Expressing HIV-1 Env 1086 Clade C Elicits Durable Humoral and Cellular Responses in Rhesus Macaques. MolTher.2016 Jul 26.doi: 10.1038/mt.2016.123.   Chamcha V, Kannanganat S, Gangadhara S, Nabi R, Kozlowski PA, Montefiori DC, LaBranche CC, Wrammert J, Keele BF, Balachandran H, Sahu S, Lifton M, Santra S, Basu R, Moss B, Robinson HL, Amara RR. Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine. Open Forum Infect Dis. 2016 Feb 11;3(1): ofw034. doi: 10.1093/ofid/ofw034. eCollection 2016 Jan.   Hulot SL, Korber B, Giorgi EE, Vandergrift N, Saunders KO, Balachandran H, Mach LV, Lifton MA, Pantaleo G, Tartaglia J, Phogat S, Jacobs B, Kibler K, Perdiguero B, Gomez CE, Esteban M, Rosati M, Felber BK, Pavlakis GN, Parks R, Lloyd K, Sutherland L, Scearce R, Letvin NL, Seaman MS, Alam SM, Montefiori D, Liao HX, Haynes BF, Santra S. Comparison of Immunogenicity in Rhesus Macaques of Transmitted-Founder, HIV-1Group M Consensus, and Trivalent Mosaic Envelope Vaccines Formulated as a DNA Prime, NYVAC, and Envelope Protein Boost. J Virol. 2015 Jun;89(12):6462-80. doi: 10.1128/JVI.00383-15. Epub 2015 Apr 8.   Asmal M, Luedemann C, Lavine CL, Mach LV, Balachandran H, Brinkley C, Denny TN, Lewis MG, Anderson H, Pal R, Sok D, Le K, Pauthner M, Hahn BH, Shaw GM, Seaman MS, Letvin NL, Burton DR, Sodroski JG, Haynes BF, Santra S. Infection of monkeys by simian-human immunodeficiency viruses with transmitted/founder clade C HIV-1 envelopes.Virology. 2015 Jan 15;475:37-45. doi: 10.1016/j.virol.2014.10.032. Epub 2014 Nov 22.   Sixsmith JD, Panas MW, Lee S, Gillard GO, White K, Lifton MA, Balachandran H, Mach L, Miller JP, Lavine C, DeMarco CT, Tomaras GD, Gee C, Porcelli SA, Larsen MH, Frothingham R, Schmitz JE, Jacobs WR Jr, Haynes BF, Letvin NL, Korioth-Schmitz B. Recombinant Bacillus Calmette-Guérin vectors prime for strong cellular responses to SIV Gag in rhesus macaques. Clin Vaccine Immunol.2014 Jul 30.pii: CVI.00324-14.   Giorgi EE, Balachandran H, Muldoon M, Letvin NL, Haynes BF, Korber BT, Santra S. Cross-reactive potential of human T-lymphocyte responses in HIV-1 infection. Vaccine. 2014 May 14. pii: S0264-410X(14)00578-7. doi: 10.1016/j.vaccine.2014.04.040   Bolton DL, Santra S, Swett‐Tapia C, Custers J, Song K, Balachandran H, Mach L, Naim H, Kozlowski PA, Lifton M, Goudsmit J, Letvin N, Roederer M, Radošević K. Priming T‐cell responses with recombinant measles vaccine vector in a heterologous prime‐boost setting in non‐human primates. Vaccine.2012 Sep7;30(41):5991‐8.doi: 10.1016/j.vaccine.2012.06.029. Epub2012 Jun 22.   Santra S, Muldoon M, Watson S, Buzby A, Balachandran H,Carlson KR, Mach L, Kong WP, McKee K, Yang ZY, Rao SS, Mascola JR, Nabel GJ, Korber BT, Letvin NL. Breadth of cellular and humoral immune responses elicited in rhesus monkeys by multi‐valent mosaic and consensus immunogens. Virology.2012 Jul 5;428(2): 121‐7. Epub 2012 Apr21.   Letvin NL, Rao SS, Montefiori DC, Seaman MS, Sun Y, Lim SY, Yeh WW, Asmal M, Gelman RS, Shen L, Hudgens MG, Gilbert PB, Buzby AP, Mach LV, Zhang J, Balachandran H, Shaw GM, Schmidt SD, Todd JP, Dodson A, Mascola JR, Nabel GJ. Immune and Genetic Correlates of Vaccine Protection against Mucosal Infection by SIV in Monkeys. SciTransl Med.2011May 4;3(81):81ra36.   Manuel ER, Yeh WW, Balachandran H, Clarke RH, Lifton MA, Letvin NL. Vaccination reduces simian‐ Human immunodeficiency virus sequence reversion through enhanced viral control. J Virol. 2010 Dec; 84(24):12782‐9.Epub2010 Sep29.   Santra S, Liao HX, Zhang R, Muldoon M, Watson S, Fischer W, Theiler J, Szinger J, Balachandran H, Buzby A, Quinn D, Parks RJ, Tsao CY, Carville A, Mansfield KG, Pavlakis GN, Felber BK, Haynes BF, Korber BT, Letvin NL. Mosaic vaccines elicit CD8+T lymphocyte responses that confer enhanced immune coverage of diverse HIV strains in monkeys. Nat Med.2010 Mar; 16(3):324‐8.Epub2010Feb 21.   Zahn RC, Rett MD, Li M, Tang H, Korioth‐Schmitz B, Balachandran H, White R, Pryputniewicz S, Letvin NL, Kaur A, Montefiori DC,Carville A, Hirsch VM, Allan JS, Schmitz JE. Suppression of adaptive immune responses during primary SIV infection of sabaeus African green monkeys delays partial containment of viremia but does not induce disease. Blood. 2010 Apr 15;115(15):3070‐8.Epub2010 Feb10.   Rodríguez A, Mintardjo R, Tax D, Gillissen G, Custer J, Pau MG, Klap J,SantraS, Balachandran H, Letvin NL, Goudsmit J, Rdosević K. Evaluation of a prime‐boost vaccine schedule with distinct adenovirus vectors against malaria inrhesusmonkeys.Vaccine.2009 Oct 19;27(44):6226‐33.Epub2009 Aug 15.   Dumka D, Puri P, Carayol N, Lumby C, Balachandran H, Schuster K, Verma AK, Terada LS, Platanias LC, Parmar S. Activation of the p38Mapkinase pathway is essential for the antileukemic effects of dasatinib. Leuk Lymphoma. 2009Dec;50(12):2017‐29.   Cayabyab MJ, Korioth‐Schmitz B, Sun Y, Carville A, Balachandran H, Miura A, Carlson KR,Buzby AP, Haynes BF, Jacobs WR, LetvinNL. Recombinant Mycobacterium bovis BCG prime‐recombinant adenovirus boost vaccination in rhesus monkeys elicits robust polyfunctional simian immunodeficiency virus‐specific T‐cell responses. J Virol.2009 Jun;83(11):5505‐13.Epub2009 Mar18.