Dr Orazio Vittorio – Targeting copper in cancer as a novel immunotherapy strategy

Event type: 
Seminar
Event date: 
Tuesday, 25 August 2020 - 1:00pm to 2:00pm
Location: 

Webinar via Microsoft Teams Live Event

Contact for inquiries: 
Rata Joseph, +61 (2) 9385 0900 or recpt@kirby.unsw.edu.au
Booking deadline: 

Webinar link: https://bit.ly/KISS200825

Kirby Institute Seminar Series presents

Dr Orazio Vittorio

Dr Orazio Vittorio
Scientia Senior Lecturer, School of Women's and Children's Health, UNSW Sydney

Dr Orazio Vittorio is Scientia Senior Lecturer at the School of Women's and Children's Health UNSW, NHMRC CDF and Team Leader at the Children’s Cancer Institute. His recent investigations are focused on understanding the role of copper (Cu) metabolism/homeostasis in cancer. Dr Vittorio's leadership in his field of research is evidenced by >80 peer-reviewed papers, 6 book chapters, 4 patents, and invitations as keynote speaker in several conferences.

Abstract

Checkpoint antibodies blocking PD1/PD-L1 signaling have improved clinical outcomes in cancer. However, this strategy has not been successful for neuroblastoma. We provided the first evidence of the role of copper in modulating PD-L1 expression and immune-evasion in neuroblastoma. This raises the potential of repurposing copper chelators to enhance antitumour immunity.

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