Infection Analytics Program

Projects

Showing projects

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Dynamics of P.vivax infection and hypnozoite reactivation

Project Status: Ongoing
The two major parasite species causing malaria are Plasmodium falciparum and Plasmodium vivax. Plasmodium vivax infection is usually less severe, but...
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Dynamics Plasmodium falciparum infection and naturally acquired immunity

Project Status: Ongoing
Plasmodium falciparum(P. falciparum) infection is one of the major causes of morbidity and mortality for individuals living in malaria endemic region...
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HIV Reactivation

Project Status: Ongoing
HIV infection can be effectively controlled byanti-retroviral therapy.  However, during  treatment the virus continues to persist in infected cells...
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Impact of vaccination against common infectious diseases

Project Status: Ongoing
Vaccines against many common infectious diseases have either been developed or are in the final stages of development by drug companies. However...
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Modelling CMV reactivation in bone marrow transplant patients

Project Status: Ongoing
In order to prepare patients for bone marrow transplant their immune cells are removed, allowing replacement with transplanted cells. However one of...
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Understanding HIV mutation and recombination

Project Status: Ongoing
The HIV virus acquires new mutations during its replication cycle, and these new mutations may be ‘reassembled’ through recombination between...
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Understanding malaria infection and treatment in human clinical trials

Project Status: Ongoing
This work aims to develop our understanding of malaria infection and treatment during human infection. We analyse data collected from a unique series...
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Understanding Neonatal Immunity

Project Status: Ongoing
Newborns are very susceptible to infection compared to adults, and also have lower responses to some vaccines.  One important type of cell which can...
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Understanding the factors that shape the T cell receptor repertoire

Project Status: Ongoing
Effective T cell recognition and immune control of infection depend on the availability of a diverse and well-balanced repertoire of T cell receptors...
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Understanding the impact of development, age, and chronic infection on the T cell repertoire

Project Status: Ongoing
Effective T cell recognition and immune control of infection depend on the availability of a diverse and well-balanced repertoire of T cell receptors...
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Understanding the interactions of Epstein-Barr virus and malaria infection

Project Status: Ongoing
Burkitt lymphoma was first discovered in 1958, and is the most common childhood cancer in equatorial Africa. Infection with both Epstein-Barr virus (...
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Understanding the role of T cell repertoire composition in T cell responses to infection and vaccination.

Project Status: Ongoing
Effective T cell recognition and immune control of infection depend on the availability of a diverse and well-balanced repertoire of T cell receptors...
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Using mouse models to understand malaria infection, treatment and immunity

Project Status: Ongoing
In malaria infection both drug treatment and host immune responses are known to be able to reduce parasite numbers and often completely “clear” the...