TREAT Asia HIV Observational Database (TAHOD)

Date Commenced:
09/2003
Project Status
Ongoing
Expected Date of Completion:
Ongoing
Project Supporters

American Foundation for AIDS Research (amfAR) via a US National Institutes of Health grant through the International Epidemiologic Databases Evaluating AIDS collaboration

Currently recruiting
Yes
TREAT Asia HIV Observational Database (TAHOD)

About the Project

TAHOD is an observational cohort study of patients with HIV at 21 sites in 12 countries throughout the Asia-Pacific region. Demographic, clinical and treatment data are aggregated twice each year via electronic data transfer.

Status: At the September 2014 data transfer, baseline and retrospective data from over 8500 patients were aggregated. It is expected that follow up will continue for at least a further three years.

Rationale

The use of combination antiretroviral therapy has led to reduced morbidity and mortality caused by HIV infection in industrialised countries. Currently, a broad range of resources for HIV/AIDS management exists in countries of the Asia-Pacific region. However, there is limited information relating to demographic factors, markers of HIV disease stage and antiretroviral treatment choices in clinic sites in most countries of the Asia-Pacific region. 

Aims

TAHOD was established in 2003 and aims to evaluate the impact of HIV disease, co-infections, and antiretroviral management on clinical outcomes in the Asia-Pacific, in order to inform optimal care and treatment for HIV disease in the region. Through a model of regional partnerships, it conducts regional epidemiologic analyses on anonymized cohort data to look at factors driving the epidemic (e.g., male-to-male sex, injection drug use), as well as responses to antiretroviral treatment, impact of co-infections (e.g., HBV, HCV, human papilloma virus, tuberculosis), toxicity of first- and second-line regimens, risk of cancer, chronic AIDS- and non-AIDS-related events and outcomes, and patterns of drug resistance.

Design & Method

TAHOD is a prospective adult observational cohort.  Each site recruits approximately 200-500 HIV-infected patients, including those not yet started on antiretroviral therapy.

The following data is collected: patient demographics, CD4 and CD8 count, HIV VL level, prior and new AIDS defining illness, date and cause of death, prior and current prescribed antiretroviral treatment, reasons for treatment change, prophylactic treatment of opportunistic infection, adverse events, various blood chemistries, antiretroviral therapy adherence, smoking status, pregnancy status, HIV drug resistance, and serious non-AIDS related events. Data are collected according to a common protocol. Prospective data are updated six monthly at each clinic and transferred to the Kirby Institute for aggregation and analyses. 

Progress/Update

In 2015 TAHOD will begin collecting more detailed information on serious non-AIDS related events and provide a basis for several important sub-studies including TAHOD-LITE. 

Project Members
image - Website5 0
Research Fellow
Ph +61 (0)2 9385 0900
image - 1338340968 Matthew Law.jpg
Professor and Program Head
Ph (02) 93850966
image - Dave Boettiger
Research Fellow
Ph +61 (0)2 9385 0859
Project Attachment
Project Collaborators: External

of 18 clinical sites at countries throughout the Asia-Pacific region

Project Coordinators
image - Website5 0
Research Fellow
Ph +61 (0)2 9385 0900
image - Dave Boettiger
Research Fellow
Ph +61 (0)2 9385 0859

Project Contacts

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