Role of ADCC in disease progression

Date Commenced:
06/2010
Project Status
Ongoing
Expected Date of Completion:
Ongoing
Project Supporters

NHMRC

Currently recruiting
No
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About the Project

Rationale

Antibody Dependent cytotoxicity is a mechanism by which Natural Killer cells kill infected cells.  Its role in control of HIV-infection and in preventing HIV infection post vaccination is unclear. It is mediated by certain isotypes of IgG.

Aims

To define quantity and quality of ADCC responses in various patient groups and look for correlations with control.

Design & Method

Studies are being undertaken with collaborators in Melbourne and Perth to determine correlates of progression and unique epitopes

Progress/Update

Samples on all LTNP and untreated patients at primary infection with varying rates of progression have been transferred to Melbourne and Perth for conduct of assays. Manuscript reporting results in LTNPs and rapid progressors has been submitted for publication.

Benefits

Further work characterising epitopes is ongoing and will be completed in 2012

Project Members
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Professor and Program Head
Ph 02 9385 0900
image - 1338430901 Pat Grey New
Ms Pat Grey
Clinical Project Co-ordinator
Other Investigators

Kat Marks

Project Collaborators: External

Long-Term Non-progressor Study Group, including clinical sites in Sydney, Port Kembla, Canberra, Brisbane and Melbourne

St Vincent’s Hospital, Sydney

Department of Immunology and Infectious Diseases, Melbourne University

Department of Immunology, Royal Perth Hospital

Project Research Area

Project Contacts

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