About the Project
Antibody Dependent cytotoxicity is a mechanism by which Natural Killer cells kill infected cells. Its role in control of HIV-infection and in preventing HIV infection post vaccination is unclear. It is mediated by certain isotypes of IgG.
To define quantity and quality of ADCC responses in various patient groups and look for correlations with control.
Design & Method
Studies are being undertaken with collaborators in Melbourne and Perth to determine correlates of progression and unique epitopes
Samples on all LTNP and untreated patients at primary infection with varying rates of progression have been transferred to Melbourne and Perth for conduct of assays. Manuscript reporting results in LTNPs and rapid progressors has been submitted for publication.
Further work characterising epitopes is ongoing and will be completed in 2012
Professor and Program Head
Ph 02 9385 0900
Ms Pat Grey
Clinical Project Co-ordinator
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Project Collaborators: External
Long-Term Non-progressor Study Group, including clinical sites in Sydney, Port Kembla, Canberra, Brisbane and Melbourne
St Vincent’s Hospital, Sydney
Department of Immunology and Infectious Diseases, Melbourne University
Department of Immunology, Royal Perth Hospital