Hepatitis C Vaccine Preparedness Studies (Hits-C)

Date Commenced:
2008
Project Status
Ongoing
Expected Date of Completion:
Ongoing
Project Supporters

NHMRC

Currently recruiting
No
image - Hepatitis C Vaccine Preparedness Study 284x284

About the Project

Rationale

The project aims to establish the feasibility of conducting field trials of candidate HCV vaccines with PWID 

Aims

1) Determine HCV incidence and spontaneous clearance in a prospective cohort of uninfected PWID; 2) Identify associated risk factors; 3) Evaluate retention strategies and factors associated with adherence to the study protocol; and 4) Investigate immunisation acceptability, clinical trial literacy and willingness to participate in future vaccine trials in this group

Design & Method

The project includes the Hepatitis C Incidence and Transmission Study – community (HITS-c), a prospective observational study of HCV antibody and RNA negative PWID. Participants who acquire HCV are enrolled in an incident case cohort, the Hepatitis C Incidence and Transmission Study – incidence (HITS-i).

Progress/Update

A total of 313 PWID were screened for the study and 188 identified as eligible and enrolled. Retention at 12 months was 85%. A total of 32 incident cases of HCV infection were  observed (6.9/100py; 95% CI 4.9.8-9.7).

Benefits

Results will inform the feasibility and design of future field trials of candidate HCV vaccines, as well as public health policy and interventions to prevent the transmission of hepatitis C in PWID.

Output

Peer-reviewed publications, conference presentations and reports. Annual estimates of HCV incidence among PWID are also published in the Kirby Institute Annual Surveillance Report.

Project Members
image - 1343190993 Bethany White1
Research Assistant
Ph +61 (0)2 9385 0900
image - 1343872980 Jarliene
Administrative Officer
Ph +61 (0)2 9385 0900
image - 1338782033 Sammy Chow
Research Assistant
Ph +61 (0)2 9385 9989
image - 1340850769 Lm Work Photo
Professor and Program Head and NHMRC Senior Research Fellow
Ph +61 (0)2 9385 0936
image - 1343873204 Jessica Jia
Research Assistant
Ph +61 (0)2 9385 0900
Other Investigators

Margaret Hellard, Annie Madden, Maria Prins, Thomas Kerr, Kimberly Page, Ju Park

Project Collaborators: External

Academic Medical Centre, University of Amsterdam and Infectious Disease Cluster, Amsterdam Public Health Service

Australian Intravenous and Injecting League (AIVL)

Hepatitis Australia

Hepatitis C Council of NSW

Inflammatory Diseases Research Unit, School of Medical Sciences, UNSW

SEALS Microbiology, Prince of Wales Hospital

Burnet Institute

British Columbia Centre for Excellence in HIV/AIDS

University of California San Francisco

Project Contacts

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