FLU 003 Plus (Respiratory Virus Hospitalization Study) - An International Observational Study to Characterize Adults Who Are Hospitalized with Complications of Influenza or Other Targeted Respiratory Viruses

Date Commenced:
09/2009
Project Status
Ongoing
Expected Date of Completion:
12/2014
Project Supporters

University of Minnesota; NIAID, USA

Currently recruiting
Yes
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About the Project

Rationale

In 2009, the world experienced the first pandemic of influenza in 40 years; the rationale for this observational study of patients hospitalised with all types of influenza is to understand better the risk factors for severe infection and poor outcomes with influenza.

Aims

To characterise and describe the outcomes over a 60-day follow-up period of those with influenza -- who are hospitalized with severe and/or complicated influenza  

Design & Method

Observational

Progress/Update

Ongoing with 657 participants enrolled globally

Benefits

The data gathered will help us understand the characteristics and outcomes over a 60-day follow-up period of participants with influenza – including pandemic 2009 H1N1who are hospitalized with severe and/or complicated influenza in geographically diverse locations. Specific objectives are to estimate the percentage of patients who die, to obtain information on risk factors for mortality, and to establish a central repository of specimens for use in virus characterization, including subtyping, antigenic and genetic analyses, identification of signature mutations associated with antiviral drug resistance, mutational evolution, and additional reassortment. This information will be used to guide policymakers and to design future studies.

Output

Conference abstracts have been presented.

Project Members
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Clinical Project Leader
Ph +61 (2) 9385 0908
Project Attachment
Other Investigators

Dr Sarah Pett, Professor Dominic Dwyer, Dr John McBride, Professor Jenny Hoy and Dr Julian Elliott.

Project Collaborators: External

St. Vincent’s Hospital

Westmead Hospital

Thailand

Japan

TVRP is also responsible for coordinating the study in Thailand (2 sites), Hong Kong (1 site), Argentina (8 sites), and Chile (2 site).

Project Research Area

Project Contacts

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