About the Project
Hepatitis C virus (HCV) infection is a public health problem however very little is known about the health of patients years following therapy, and whether HCV treatment at an early stage continues to be beneficial to people. The Australian Trial in Acute Hepatitis C (ATAHC) previously enrolled 163 subjects with recent (ie acute or early chronic) HCV infection between 2004 and 2008. Uptake of treatment was high, with 79% initiating therapy. Follow-up was maintained for up to 2 years post SVR with continued specimen and data collection, with 7 reinfections observed during this time. The study closed in 2007 and the original subjects are now an average of 5.6 years from initial infection. The ATAHC study demonstrated the successful recruitment, engagement and early follow-up of one of the largest international cohorts of individuals with AHC and established one of the most extensive serum, plasma and PBMC storage banks of AHC worldwide. Longitudinal follow-up at this point will allow for the first international, long-term assessment of clinical, social, behavioural, psychological and immunovirological outcomes. It will provide diagnostic data to translate into clinical practice guidelines for recent HCV infection treatment.
To evaluate the effect of successful prior treatment of spontaneous clearance of recently acquired HCV infection on long-term quality of life, social functioning, injecting behaviour, mental health and liver health.
To assess the incidence of HCV re-infection following prior treatment induced clearance or spontaneous clearance of recently acquired chronic HCV infection.
To determine predictors of HCV re-infection following recently acquired HCV infection treatment.
To determine frequency and predictors of new mixed and superinfections in ATAHC subjects with persistent HCV viraemia.
To add to a tissue repository of serum and PBMCs from well-characterised patients treated for recently acquired HCV infection to allow future examination of the role of other variables that may potentially impact on the prognosis and outcomes of early HCV treatment.
Design & Method
A single long-term follow up assessment of an established multi-centre, prospective longitudinal cohort study of patients for clinical, psychosocial, immunovirological outcomes 4 to 8 years after previous treatment for recently acquired hepatitis C virus infection.
There are currently no patients enrolled.
Ph +61 2 9385 0877
Senior Research Fellow (UNSW)
Ph +61 (2) 9385 0957
Professor and Program Head
Ph 02 9385 0900
Clinical Trials Manager
Ph +61 (0)2 9385 0886
Post Graduate Research Candidate
Ph +61 (0)2 9385 0230
Senior Research Officer
Ph +61 (0)2 9385 0900
Clinical Project Coordinator
Ph +61 2 9385 0882
Mr Austin Butcher
A/Professor Margaret Hellard
Dr Joseph Doyle
Dr David Shaw
Project Collaborators: External
St Vincent’s Hospital, Sydney
The Alfred Hospital, Melbourne
Royal Adelaide Hospital, Adelaide