The laboratory concentrates on comparing the interaction between virus and the immune system in treated and untreated individuals with HIV-infection in an attempt to define protective immune responses with the objective of applying these observations to rational treatment and vaccine design. We have established an exciting new area of research on transcriptional gene silencing of HIV-1 by siRNAs. We have developed and patented new methodologies for describing Treg cells and antigen specific cells which are providing new insights into immunopathogenesis and vaccine design. These assays will allow novel mapping of the mechanisms underlying the estbalishment and maintenance of the viral reservoirs which is the roadblock to curing this infection.
Broad Research Areas:
HIV - AIDS, Immunology, Infectious Diseases, Virology
MBBS, PhD, FRACP, FRCPA
Society Memberships & Professional Activities:
FRACP, FRCPA, ASHM, ASI, Ammerican Society of Immunologists
Specific Research Keywords:
HIV/AIDS, Immunology, Immunology and Infectious Disease, Virology, siRNA